HLA-B45 explained


HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B45
Alleles	B*4501, 4502 . .
Structure (See HLA-B)
Shared data
	chr.6 6p21.31

HLA-B45 (B45) is an HLA-B serotype. The serotype identifies the B*45 gene-allele protein products of HLA-B.^[1]

B45 is a split antigen of the broad antigen B12, and is a sister type of B44.Gene products of 45 not 44

Serotype

Serotypes B45, B12, and B44 recognition of the
HLA B*44 gene products^[2]
B*45	B45	B12	B45	Sample
allele	%	%	%	size (N)
4501	93	1	1	2307
4502	75			4
Alleles link-out to IMGT/HLA Databease at EBI

Alleles

It was reported that a novel haplotype was found in Italian bone marrow donors. A2-CW*1601-B45- DRB1*1101-DRB3*0301-DQA1*0102-DQB1*0502. This haplotype indicates possible very recent ancestry from Africa, with the Cw*1601 and B45 components and also with the DR11-DQ5.2 component both extremely rare in Europe.^[3]

Notes and References

2848993 . 2010 . Marsh . S. G. . Nomenclature for factors of the HLA system, 2010 . Tissue Antigens . 75 . 4 . 291–455 . Albert . E. D. . Bodmer . W. F. . Bontrop . R. E. . Dupont . B. . Erlich . H. A. . Fernández-Viña . M. . Geraghty . D. E. . Holdsworth . R. . Hurley . C. K. . Lau . M. . Lee . K. W. . Mach . B. . Maiers . M. . Mayr . W. R. . Müller . C. R. . Parham . P. . Petersdorf . E. W. . Sasazuki . T. . Strominger . J. L. . Svejgaard . A. . Terasaki . P. I. . Tiercy . J. M. . Trowsdale . J. . 20356336 . 10.1111/j.1399-0039.2010.01466.x .
http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA
Daielli C, Salvaneschi L, Ghidini G, Ambroselli F, Gatti C, Martinetti M . A novel Italian haplotype predominates in HLA-B45-positive bone marrow donors: HLA-A2, CW*1601, B45, DRB1*1101, DRB3*0301, DQA1*0102, DQB1*0502 . Tissue Antigens . 47 . 4 . 341–3 . April 1996 . 8773326 . 10.1111/j.1399-0039.1996.tb02564.x.