HLA-B44 explained
|
| HLA-B (alpha)-β2MG with bound peptide |
major histocompatibility complex (human), class I, B44
|
| Alleles | B*4401, 4402, 4403 . . |
| Structure (See HLA-B) |
| Shared data |
| chr.6 6p21.31 | |
HLA-B44 (B44) is an
HLA-
B serotype. The serotype identifies the B*44 gene-allele protein products of HLA-B.
[1] B44 is a split antigen of the broad antigen B12, and is a sister type of B45.
Serotype
Serotypes B44, B12, and B45 recognition of the
HLA B*44 gene products[2] | B*44 | B44 | B12 | B45 | Sample |
| allele | % | % | % | size (N) |
| 4402 | 98 | | | 6959 |
| 4403 | 94 | | | 2854 |
| 4404 | 65 | | | 42 |
| 4405 | 92 | | | 130 |
| 4406 | 44 | | | 9 |
| B*4401 was shown to be B*4402 after errors corrected. |
| Alleles link-out to IMGT/HLA Database at EBI | |
Disease
HLA-B44 increases recurrent sinopulmonary infections.[3] Protective effects: HLA-B44 appears to be protective against autoimmune lymphoproliferative syndrome in patients with C95 defect (ALPS type Ia).[4] B44 may be a cofactor in ankylosing spondylitis[5]
Notes and References
- 2848993 . 2010 . Marsh . S. G. . Nomenclature for factors of the HLA system, 2010 . Tissue Antigens . 75 . 4 . 291–455 . Albert . E. D. . Bodmer . W. F. . Bontrop . R. E. . Dupont . B. . Erlich . H. A. . Fernández-Viña . M. . Geraghty . D. E. . Holdsworth . R. . Hurley . C. K. . Lau . M. . Lee . K. W. . Mach . B. . Maiers . M. . Mayr . W. R. . Müller . C. R. . Parham . P. . Petersdorf . E. W. . Sasazuki . T. . Strominger . J. L. . Svejgaard . A. . Terasaki . P. I. . Tiercy . J. M. . Trowsdale . J. . 20356336 . 10.1111/j.1399-0039.2010.01466.x .
- http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA
- Johnston DT, Mehaffey G, Thomas J, etal . Increased frequency of HLA-B44 in recurrent sinopulmonary infections (RESPI) . Clin. Immunol. . 119 . 3 . 346–50 . June 2006 . 16542878 . 10.1016/j.clim.2006.02.001 .
- Vacek MM, Schäffer AA, Davis J, etal . HLA B44 is associated with decreased severity of autoimmune lymphoproliferative syndrome in patients with CD95 defects (ALPS type Ia) . Clin. Immunol. . 118 . 1 . 59–65 . January 2006 . 16257267 . 10.1016/j.clim.2005.09.006 .
- Purrmann J, Zeidler H, Bertrams J, etal . HLA antigens in ankylosing spondylitis associated with Crohn's disease. Increased frequency of the HLA phenotype B27,B44 . J. Rheumatol. . 15 . 11 . 1658–61 . November 1988 . 3266250 .
