HLA-B38 explained

HLA-B (alpha)-β2MG with bound peptide

major histocompatibility complex (human), class I, B38

Alleles B*3801, 3802, . .
Structure (See HLA-B)
Shared data
chr.6 6p21.31
HLA-B38 (B38) is an HLA-B serotype. The serotype identifies the B*38 allele products of the HLA-B gene-locus.[1]

B38 is a split antigen of the broad antigen B16, and is a sister type of B39. The B*3801 allele is more common in Eastern, Southern and Southeastern Europe, while the B*3802 allele is more common in the Far East.

Serotype

Serotypes B38, B16, and B39 recognition of the
HLA B*39 gene products[2]
B*38 B38 B16 B39 Sample
allele % % % size (N)
3801 94 1 1 2317
3802 87 2 2 788
Alleles link-out to IMGT/HLA Databease at EBI

Alleles

HLA B*3801 frequencies
freq
ref. Population (%)
[3] Israel Ashk. and Non Ashk. Jews6.9
Croatia6.7
Italy North6.7
Azores Central Islands5.4
Sudanese5.3
Czech Republic4.7
Georgia Tbilisi Georgians4.6
Macedonia (4)4.6
Spain Eastern Andalusia4.1
Georgia Svaneti Svans3.8
New Mexico Canoncito Navajo3.7
Bulgaria3.6
Brazil Belo Horizonte3.2
Romanian3.2
Tunisia3.0
Thailand2.8
Israel Arab Druse2.5
USA Caucasian (2)2.5
Tunisia Tunis2.3
Brazil2.2
Indig. Australian Cape York Penin.2.0
France South East1.9
Georgia Tbilisi Kurds1.7
Australia New South Wales1.5
China Guangzhou1.5
Mexico Guadalajara Mestizos (2)1.5
China Yunnan Lisu1.4
Jordan Amman1.4
Morocco Nador Metalsa Class I1.4
China South Han1.2
Mexico Mestizos1.2
Saudi Arabia Guraiat and Hail1.2
Finland1.1
USA North American Natives1.1
American Samoa1.0
China North Han1.0
India North Hindus1.0
Mexico Mixtec Oaxaca1.0
Hong Kong Chinese0.9
Ireland Northern0.9
Cape Verde Southeastern Islands0.8
China Beijing0.8
Ireland South0.8

Disease

A higher frequency of HLA-B38 was noted psoriatic arthritis patients with erythroderma.[4] Psoriatic arthritis is linked to MICA and/or B39 in other peoples.[5] In Pemphigus vulgaris a haplotype containing B38 was identified and found to be shared between Spanish and Jewish patients.[6] Linkage studies indicate a factor in the HLA-class I region is more greatly associated, with HLA-B38 so far the only linked allele[7]

HLA B*3802 frequencies
freq
ref. Population (%)
Taiwan Tao11.0
China Guangxi Maonan8.3
China South Han7.1
Singapore Javan. Indonesians7.1
Singapore Chinese Han6.4
Taiwan Minnan pop 16.4
China Guangzhou6.0
Philippines Ivatan6.0
Hong Kong Chinese5.4
Singapore Chinese4.7
Singapore Riau Malay4.5
China Guangzhou Han4.3
India West Bhils4.0
Taiwan Hakka3.6
Singapore Thai3.5
Taiwan Siraya2.9
Taiwan Pazeh1.8
India Mumbai Marathas1.2
South Korea pop 31.1
Taiwan Puyuma1.0
Taiwan Saisiat1.0
China Beijing0.8
Brazil0.7

Notes and References

  1. 2848993 . 2010 . Marsh . S. G. . Nomenclature for factors of the HLA system, 2010 . Tissue Antigens . 75 . 4 . 291–455 . Albert . E. D. . Bodmer . W. F. . Bontrop . R. E. . Dupont . B. . Erlich . H. A. . Fernández-Viña . M. . Geraghty . D. E. . Holdsworth . R. . Hurley . C. K. . Lau . M. . Lee . K. W. . Mach . B. . Maiers . M. . Mayr . W. R. . Müller . C. R. . Parham . P. . Petersdorf . E. W. . Sasazuki . T. . Strominger . J. L. . Svejgaard . A. . Terasaki . P. I. . Tiercy . J. M. . Trowsdale . J. . 20356336 . 10.1111/j.1399-0039.2010.01466.x .
  2. http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA
  3. Middleton D, Menchaca L, Rood H, Komerofsky R . New allele frequency database . Tissue Antigens . 61 . 5 . 403–7 . 2003 . 12753660 . 10.1034/j.1399-0039.2003.00062.x . free .
  4. Imre K, Koó E, Seszták M, Bosák V, Bitterova O . [Genetics in patients with psoriatic arthritis] . hu . Orv Hetil . 147 . 50 . 2415–9 . December 2006 . 17274187 .
  5. Eastmond CJ . Psoriatic arthritis. Genetics and HLA antigens . Baillière's Clinical Rheumatology . 8 . 2 . 263–76 . May 1994 . 8076387 . 10.1016/S0950-3579(94)80018-9.
  6. Loewenthal R, Slomov Y, Gonzalez-Escribano MF, etal . Common ancestral origin of pemphigus vulgaris in Jews and Spaniards: a study using microsatellite markers . Tissue Antigens . 63 . 4 . 326–34 . April 2004 . 15009804 . 10.1111/j.0001-2815.2004.00191.x .
  7. Slomov E, Loewenthal R, Goldberg I, Korostishevsky M, Brenner S, Gazit E . Pemphigus vulgaris in Jewish patients is associated with HLA-A region genes: mapping by microsatellite markers . Hum. Immunol. . 64 . 8 . 771–9 . August 2003 . 12878355 . 10.1016/S0198-8859(03)00092-2.