major histocompatibility complex (human), class I, B18 | ||
| Alleles | B*1801 | |
| Alleles | B*1802 | |
| Alleles | B*1803 | |
| Structure (See HLA-B) | ||
| Symbol(s) | HLA-B | |
| EBI-HLA | B*1801 | |
| EBI-HLA | B*1802 | |
| EBI-HLA | B*1803 | |
| Locus | chr.6 6p21.31 | |
HLA-B18 (B18) is an HLA-B serotype. The serotype identifies the more common HLA-B*18 gene products.[1] (For terminology help see: HLA-serotype tutorial) B*1801, the most common allele is at highest frequencies in Northern Italy and the Balkans, a peak frequency distribution it shares with B*3501.
B*18:06 is one of the four B alleles that reacts with neither Bw4 nor Bw6. The others are B*46:01, B*55:03, and B*73:01.[2]
| B*18 | B18 | Sample | ||
| allele | % | % | size (N) | |
| 1801 | 96 | 1641 | ||
| 1802 | 90 | 31 | ||
| 1803 | 83 | 29 |
| freq | |||
| ref. | Population | (%) | |
| [4] | Italy North pop 1 | 16.7 | |
| Croatia | 11.3 | ||
| Georgia Svaneti Svans | 11.3 | ||
| Romanian | 11.3 | ||
| Portugal South | 11.2 | ||
| Singapore Riau Malay | 9.9 | ||
| Bulgaria | 9.1 | ||
| Israel Arab Druse | 8.5 | ||
| Azores Central Islands | 8.0 | ||
| Portugal Centre | 8.0 | ||
| Finland | 7.8 | ||
| Azores Santa Maria and Sao Miguel | 7.7 | ||
| Czech Republic | 7.5 | ||
| India Jalpaiguri Toto | 7.5 | ||
| Iran Baloch | 7.1 | ||
| Philippines Ivatan | 7.0 | ||
| Thailand | 6.7 | ||
| Tunisia | 6.7 | ||
| Portugal North | 6.5 | ||
| Zimbabwe Harare Shona | 6.4 | ||
| Madeira | 6.2 | ||
| Mexico Mestizos | 6.1 | ||
| Kenya | 5.9 | ||
| Belgium | 5.1 | ||
| Morocco Nador Metalsa Class I | 5.1 | ||
| Singapore Javanese Indonesians | 5.1 | ||
| Israel Ashkenazi and Non Ashkenazi Jews | 5.0 | ||
| Uganda Kampala | 5.0 | ||
| Kenya Nandi | 4.8 | ||
| Oman | 4.7 | ||
| Georgia Tbilisi Georgians | 4.6 | ||
| Bulgaria Gipsy | 4.5 | ||
| France South East | 4.3 | ||
| Kenya Luo | 4.3 | ||
| Ireland South | 4.2 | ||
| Russia Arkhangelsk Pomors | 4.0 | ||
| Azores Terceira Island | 3.9 | ||
| Guinea Bissau | 3.8 | ||
| India New Delhi | 3.8 | ||
| Spain Eastern Andalusia Gipsy | 3.5 | ||
| Australia New South Wales | 3.4 | ||
| Georgia Tbilisi Kurds | 3.4 | ||
| Zambia Lusaka | 3.4 | ||
| Cameroon Yaounde | 2.7 | ||
| Senegal Niokholo Mandenka | 2.7 | ||
| Cameroon Beti | 2.3 | ||
| Ivory Coast Akan Adiopodoume | 2.3 | ||
| Sudanese | 2.3 | ||
| Saudi Arabia Guraiat and Hail | 2.2 | ||
| South African Natal Zulu | 2.0 | ||
| Thailand | 2.0 | ||
| India Mumbai Marathas | 1.9 | ||
| New Caledonia | 1.9 | ||
| Papua New Guinea Wanigela | 1.5 | ||
| Cameroon Bamileke | 1.3 |