HIVEP3 explained

Transcription factor HIVEP3 is a protein that in humans is encoded by the HIVEP3 gene.^{[1] [2]}

Function

Members of the ZAS family, such as ZAS3 (HIVEP3), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine -rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM]^[2]

It regulates osteoblasts.^[3]

Interactions

HIVEP3 has been shown to interact with TRAF1^[4] and TRAF2.^[4]

Further reading

• Rustgi AK, Van 't Veer LJ, Bernards R . Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties . Proceedings of the National Academy of Sciences of the United States of America . 87 . 22 . 8707–8710 . November 1990 . 2247438 . 55028 . 10.1073/pnas.87.22.8707 . free . 1990PNAS...87.8707R .
• Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O . Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 7 . 4 . 273–281 . August 2000 . 10997877 . 10.1093/dnares/7.4.271 . free .
• Oukka M, Kim ST, Lugo G, Sun J, Wu LC, Glimcher LH . A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2 . Molecular Cell . 9 . 1 . 121–131 . January 2002 . 11804591 . 10.1016/S1097-2765(01)00434-8 . free .
• Oukka M, Wein MN, Glimcher LH . Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells . The Journal of Experimental Medicine . 199 . 1 . 15–24 . January 2004 . 14707112 . 1887724 . 10.1084/jem.20030421 .
• Qin H, Wang J, Liang Y, Taniguchi Y, Tanigaki K, Han H . RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2 . Nucleic Acids Research . 32 . 4 . 1492–1501 . 2004 . 14999091 . 390284 . 10.1093/nar/gkh295 .
• Hong JW, Wu LC . Structural characterization of the gene encoding the large zinc finger protein ZAS3: implication to the origin of multiple promoters in eukaryotic genes . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1681 . 2–3 . 74–87 . January 2005 . 15627499 . 10.1016/j.bbaexp.2004.10.004 .
• Bettelli E, Dastrange M, Oukka M . Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells . Proceedings of the National Academy of Sciences of the United States of America . 102 . 14 . 5138–5143 . April 2005 . 15790681 . 555574 . 10.1073/pnas.0501675102 . free . 2005PNAS..102.5138B .
• Li YJ, Deng J, Mayhew GM, Grimsley JW, Huo X, Vance JM . Investigation of the PARK10 gene in Parkinson disease . Annals of Human Genetics . 71 . Pt 5 . 639–647 . September 2007 . 17388942 . 10.1111/j.1469-1809.2007.00353.x . 22122597 . free .

Notes and References

1. Hicar MD, Liu Y, Allen CE, Wu LC . Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2 . Genomics . 71 . 1 . 89–100 . January 2001 . 11161801 . 10.1006/geno.2000.6425 .
2. Web site: Entrez Gene: HIVEP3 human immunodeficiency virus type I enhancer binding protein 3.
3. Glimcher LH, Jones DC, Wein MN . Control of postnatal bone mass by the zinc finger adapter protein Schnurri-3 . Annals of the New York Academy of Sciences . 1116 . 1 . 174–181 . November 2007 . 18083927 . 10.1196/annals.1402.044 . 25260678 . 2007NYASA1116..174G .
4. Oukka M, Kim ST, Lugo G, Sun J, Wu LC, Glimcher LH . A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2 . Molecular Cell . 9 . 1 . 121–131 . January 2002 . 11804591 . 10.1016/S1097-2765(01)00434-8 . free .