HIVEP2 explained

Transcription factor HIVEP2 is a protein that in humans is encoded by the HIVEP2 gene.^{[1] [2] [3]}

Function

Members of the ZAS family, such as ZAS2 (HIVEP2), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM]

Further reading

• van 't Veer LJ, Lutz PM, Isselbacher KJ, Bernards R . Structure and expression of major histocompatibility complex-binding protein 2, a 275-kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class I genes . Proceedings of the National Academy of Sciences of the United States of America . 89 . 19 . 8971–5 . October 1992 . 1409593 . 50046 . 10.1073/pnas.89.19.8971 . 1992PNAS...89.8971V . free .
• Rustgi AK, Van 't Veer LJ, Bernards R . Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties . Proceedings of the National Academy of Sciences of the United States of America . 87 . 22 . 8707–10 . November 1990 . 2247438 . 55028 . 10.1073/pnas.87.22.8707 . 1990PNAS...87.8707R . free .
• Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M . Generation and analysis of 280,000 human expressed sequence tags . Genome Research . 6 . 9 . 807–28 . September 1996 . 8889549 . 10.1101/gr.6.9.807 . free .
• Dörflinger U, Pscherer A, Moser M, Rümmele P, Schüle R, Buettner R . Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain . Molecular and Cellular Biology . 19 . 5 . 3736–47 . May 1999 . 10207097 . 84194 . 10.1128/mcb.19.5.3736.
• Zajac-Kaye M, Ben-Baruch N, Kastanos E, Kaye FJ, Allegra C . Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells . The Biochemical Journal . 345 . 3 . 535–41 . February 2000 . 10642512 . 1220788 . 10.1042/0264-6021:3450535 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . January 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .

Notes and References

1. Sudo T, Ozawa K, Soeda EI, Nomura N, Ishii S . Mapping of the human gene for the human immunodeficiency virus type 1 enhancer binding protein HIV-EP2 to chromosome 6q23-q24 . Genomics . 12 . 1 . 167–70 . January 1992 . 1733857 . 10.1016/0888-7543(92)90423-P .
2. Nomura N, Zhao MJ, Nagase T, Maekawa T, Ishizaki R, Tabata S, Ishii S . HIV-EP2, a new member of the gene family encoding the human immunodeficiency virus type 1 enhancer-binding protein. Comparison with HIV-EP1/PRDII-BF1/MBP-1 . The Journal of Biological Chemistry . 266 . 13 . 8590–4 . May 1991 . 10.1016/S0021-9258(18)93015-2 . 2022670 . free .
3. Web site: Entrez Gene: HIVEP2 human immunodeficiency virus type I enhancer binding protein 2.