HIVEP1 explained

Zinc finger protein 40 is a protein that in humans is encoded by the HIVEP1 gene.^{[1] [2]}

Members of the ZAS family, such as ZAS1 (HIVEP1), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM]

Further reading

• Omichinski JG, Clore GM, Robien M, etal . High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1 . Biochemistry . 31 . 16 . 3907–17 . 1992 . 1567844 . 10.1021/bi00131a004 .
• Nakamura T, Donovan DM, Hamada K, etal . Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes . Mol. Cell. Biol. . 10 . 7 . 3700–8 . 1990 . 1694016 . 10.1128/mcb.10.7.3700. 360816 .
• Muchardt C, Seeler JS, Nirula A, etal . Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products . J. Virol. . 66 . 1 . 244–50 . 1992 . 1727488 . 10.1128/JVI.66.1.244-250.1992. 238281 .
• Fan CM, Maniatis T . A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence . Genes Dev. . 4 . 1 . 29–42 . 1990 . 2106471 . 10.1101/gad.4.1.29 . free .
• Baldwin AS, LeClair KP, Singh H, Sharp PA . A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes . Mol. Cell. Biol. . 10 . 4 . 1406–14 . 1990 . 2108316 . 10.1128/mcb.10.4.1406. 362243 .
• Omichinski JG, Clore GM, Appella E, etal . High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution . Biochemistry . 29 . 40 . 9324–34 . 1991 . 2248949 . 10.1021/bi00492a004 .
• Maekawa T, Sakura H, Sudo T, Ishii S . Putative metal finger structure of the human immunodeficiency virus type 1 enhancer binding protein HIV-EP1 . J. Biol. Chem. . 264 . 25 . 14591–3 . 1989 . 10.1016/S0021-9258(18)63733-0 . 2504707 . free .
• Otsuka M, Fujita M, Aoki T, etal . Novel zinc chelators with dual activity in the inhibition of the kappa B site-binding proteins HIV-EP1 and NF-kappa B . J. Med. Chem. . 38 . 17 . 3264–70 . 1995 . 7650680 . 10.1021/jm00017a011 .
• Seeler JS, Muchardt C, Suessle A, Gaynor RB . Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression . J. Virol. . 68 . 2 . 1002–9 . 1994 . 8289330 . 10.1128/JVI.68.2.1002-1009.1994. 236538 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Colland F, Jacq X, Trouplin V, etal . Functional proteomics mapping of a human signaling pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Wissmüller S, Kosian T, Wolf M, etal . The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors . Nucleic Acids Res. . 34 . 6 . 1735–44 . 2006 . 16582099 . 10.1093/nar/gkl105 . 1421504 .
• Lim J, Hao T, Shaw C, etal . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .

Notes and References

1. Richard Gaynor. Gaynor RB, Muchardt C, Diep A, Mohandas TK, Sparkes RS, Lusis AJ . Localization of the zinc finger DNA-binding protein HIV-EP1/MBP-1/PRDII-BF1 to human chromosome 6p22.3-p24 . Genomics . 9 . 4 . 758–61 . Jul 1991 . 2037300 . 10.1016/0888-7543(91)90371-K .
2. Web site: Entrez Gene: HIVEP1 human immunodeficiency virus type I enhancer binding protein 1.