HIV-2 protease explained

HIV-2 retropepsin
Ec Number:	3.4.23.47
Cas Number:	144114-21-6

HIV-2 protease or retropepsin is an enzyme.^{[1] [2]} This enzyme catalyses the following chemical reaction

Endopeptidase for which the P1 residue is preferably hydrophobic

This enzyme belongs to the peptidase family A2.

Notes and References

1. Tözsér J, Bláha I, Copeland TD, Wondrak EM, Oroszlan S . Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins . FEBS Letters . 281 . 1–2 . 77–80 . April 1991 . 2015912 . 10.1016/0014-5793(91)80362-7 . free .
2. Chen Z, Li Y, Chen E, Hall DL, Darke PL, Culberson C, Shafer JA, Kuo LC . Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases . The Journal of Biological Chemistry . 269 . 42 . 26344–8 . October 1994 . 10.1016/S0021-9258(18)47199-2 . free . 7929352 .