HIST3H3 explained

Histone H3.1t is a protein that in humans is encoded by the HIST3H3 gene.^{[1] [2]}

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.^[3]

Further reading

• Govin J, Caron C, Rousseaux S, Khochbin S . Testis-specific histone H3 expression in somatic cells. . Trends Biochem. Sci. . 30 . 7 . 357–9 . 2005 . 15922600 . 10.1016/j.tibs.2005.05.001 .
• Bernués J, Espel E, Querol E . Identification of the core-histone-binding domains of HMG1 and HMG2. . Biochim. Biophys. Acta . 866 . 4 . 242–51 . 1986 . 3697355 . 10.1016/0167-4781(86)90049-7.
• Ishimi Y, Ichinose S, Omori A, etal . Binding of human minichromosome maintenance proteins with histone H3. . J. Biol. Chem. . 271 . 39 . 24115–22 . 1996 . 8798650 . 10.1074/jbc.271.39.24115 . free .
• Mizzen CA, Yang XJ, Kokubo T, etal . The TAF(II)250 subunit of TFIID has histone acetyltransferase activity. . Cell . 87 . 7 . 1261–70 . 1997 . 8980232 . 10.1016/S0092-8674(00)81821-8 . 18409257 . free .
• Witt O, Albig W, Doenecke D . Testis-specific expression of a novel human H3 histone gene. . Exp. Cell Res. . 229 . 2 . 301–6 . 1997 . 8986613 . 10.1006/excr.1996.0375 .
• Rodriguez P, Munroe D, Prawitt D, etal . Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone. . Genomics . 44 . 3 . 253–65 . 1997 . 9325046 . 10.1006/geno.1997.4868 .
• Albig W, Doenecke D . The human histone gene cluster at the D6S105 locus. . Hum. Genet. . 101 . 3 . 284–94 . 1998 . 9439656 . 10.1007/s004390050630 . 38539096 .
• El Kharroubi A, Piras G, Zensen R, Martin MA . Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. . Mol. Cell. Biol. . 18 . 5 . 2535–44 . 1998 . 9566873 . 10.1128/mcb.18.5.2535. 110633 .
• Zhang Y, Sun ZW, Iratni R, etal . SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. . Mol. Cell . 1 . 7 . 1021–31 . 1998 . 9651585 . 10.1016/S1097-2765(00)80102-1 . free .
• Lorain S, Quivy JP, Monier-Gavelle F, etal . Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA. . Mol. Cell. Biol. . 18 . 9 . 5546–56 . 1998 . 9710638 . 10.1128/MCB.18.9.5546. 109139 .
• Becker W, Weber Y, Wetzel K, etal . Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. . J. Biol. Chem. . 273 . 40 . 25893–902 . 1998 . 9748265 . 10.1074/jbc.273.40.25893 . free .
• Carrier F, Georgel PT, Pourquier P, etal . Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. . Mol. Cell. Biol. . 19 . 3 . 1673–85 . 1999 . 10022855 . 10.1128/MCB.19.3.1673. 83961 .
• Sassone-Corsi P, Mizzen CA, Cheung P, etal . Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3. . Science . 285 . 5429 . 886–91 . 1999 . 10436156 . 10.1126/science.285.5429.886 .
• Thomson S, Clayton AL, Hazzalin CA, etal . The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase. . EMBO J. . 18 . 17 . 4779–93 . 1999 . 10469656 . 10.1093/emboj/18.17.4779 . 1171550 .
• Hsieh YJ, Kundu TK, Wang Z, etal . The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. . Mol. Cell. Biol. . 19 . 11 . 7697–704 . 1999 . 10523658 . 10.1128/mcb.19.11.7697. 84812 .
• Cheung P, Tanner KG, Cheung WL, etal . Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation. . Mol. Cell . 5 . 6 . 905–15 . 2000 . 10911985 . 10.1016/S1097-2765(00)80256-7 . free .
• Buggy JJ, Sideris ML, Mak P, etal . Cloning and characterization of a novel human histone deacetylase, HDAC8. . Biochem. J. . 350 . 1. 199–205 . 2001 . 10926844 . 10.1042/0264-6021:3500199. 1221242 .
• Deng L, de la Fuente C, Fu P, etal . Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. . Virology . 277 . 2 . 278–95 . 2001 . 11080476 . 10.1006/viro.2000.0593 . free .
• Seo SB, McNamara P, Heo S, etal . Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein. . Cell . 104 . 1 . 119–30 . 2001 . 11163245 . 10.1016/S0092-8674(01)00196-9 . 11144887 . free .

Notes and References

1. Albig W, Ebentheuer J, Klobeck G, Kunz J, Doenecke D . A solitary human H3 histone gene on chromosome 1 . Hum Genet . 97 . 4 . 486–91 . Dec 1996 . 8834248 . 10.1007/BF02267072 . 27799958 .
2. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ . The human and mouse replication-dependent histone genes . Genomics . 80 . 5 . 487–98 . Oct 2002 . 12408966 . 10.1016/S0888-7543(02)96850-3 .
3. Web site: Entrez Gene: HIST3H3 histone cluster 3, H3.