HIST1H4L explained

Histone H4 is a protein that in humans is encoded by the HIST1H4L gene.^{[1] [2] [3] [4]}

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.

Further reading

• Lusic M, Marcello A, Cereseto A, Giacca M . Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter . EMBO J. . 22 . 24 . 6550–61 . 2004 . 14657027 . 10.1093/emboj/cdg631 . 291826 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Deng L . Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA . Virology . 289 . 2 . 312–26 . 2001 . 11689053 . 10.1006/viro.2001.1129 . vanc. Wang D . de la Fuente C . 3 . Wang . L . Li . H . Lee . CG . Donnelly . R . Wade . JD . Lambert . P . free .
• Deng L . Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones . Virology . 277 . 2 . 278–95 . 2001 . 11080476 . 10.1006/viro.2000.0593 . vanc. de la Fuente C . Fu P . 3 . Wang . L . Donnelly . R . Wade . JD . Lambert . P . Li . H . Lee . CG . free .
• El Kharroubi A, Piras G, Zensen R, Martin MA . Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter . Mol. Cell. Biol. . 18 . 5 . 2535–44 . 1998 . 9566873 . 10.1128/mcb.18.5.2535. 110633 .

Notes and References

1. Albig W, Meergans T, Doenecke D . Characterization of the H1.5 gene completes the set of human H1 subtype genes . Gene . 184 . 2 . 141–8 . Mar 1997 . 9031620 . 10.1016/S0378-1119(96)00582-3 .
2. Albig W, Doenecke D . The human histone gene cluster at the D6S105 locus . Hum Genet . 101 . 3 . 284–94 . Feb 1998 . 9439656 . 10.1007/s004390050630 . 38539096 .
3. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ . The human and mouse replication-dependent histone genes . Genomics . 80 . 5 . 487–98 . Oct 2002 . 12408966 . 10.1016/S0888-7543(02)96850-3 .
4. Web site: Entrez Gene: HIST1H4L histone cluster 1, H4l.