HIST1H3C explained

Histone H3.1 is a protein that in humans is encoded by the HIST1H3C gene.^{[1] [2] [3] [4]}

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes, and functions in the compaction of chromatin into higher order structures.

This gene is intronless, and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails, instead containing a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.^[5]

Further reading

• Albig W, Doenecke D . The human histone gene cluster at the D6S105 locus. . . 101 . 3 . 284–94 . 1998 . 9439656 . 10.1007/s004390050630 . 38539096 .
• El Kharroubi A, Piras G, Zensen R, Martin MA . Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. . . 18 . 5 . 2535–44 . 1998 . 9566873 . 10.1128/mcb.18.5.2535. 110633 .
• Munakata T, Adachi N, Yokoyama N, etal . A human homologue of yeast anti-silencing factor has histone chaperone activity. . . 5 . 3 . 221–33 . 2000 . 10759893 . 10.1046/j.1365-2443.2000.00319.x . 20198031 . free .
• Hsu JY, Sun ZW, Li X, etal . Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. . . 102 . 3 . 279–91 . 2000 . 10975519 . 10.1016/S0092-8674(00)00034-9 . 16057773 . free .
• Deng L, de la Fuente C, Fu P, etal . Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. . . 277 . 2 . 278–95 . 2001 . 11080476 . 10.1006/viro.2000.0593 . free .
• Lachner M, O'Carroll D, Rea S, etal . Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. . . 410 . 6824 . 116–20 . 2001 . 11242053 . 10.1038/35065132 . 2001Natur.410..116L . 4331863 .
• Deng L, Wang D, de la Fuente C, etal . Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. . Virology . 289 . 2 . 312–26 . 2001 . 11689053 . 10.1006/viro.2001.1129 . free .
• Yang L, Xia L, Wu DY, etal . Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor. . . 21 . 1 . 148–52 . 2002 . 11791185 . 10.1038/sj.onc.1204998 . 10912876 .
• Nielsen PR, Nietlispach D, Mott HR, etal . Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9. . Nature . 416 . 6876 . 103–7 . 2002 . 11882902 . 10.1038/nature722 . 2002Natur.416..103N . 4423019 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Umehara T, Horikoshi M . Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis. . . 278 . 37 . 35660–7 . 2003 . 12842904 . 10.1074/jbc.M303549200 . free .
• Lusic M, Marcello A, Cereseto A, Giacca M . Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. . . 22 . 24 . 6550–61 . 2004 . 14657027 . 10.1093/emboj/cdg631 . 291826 .
• Black BE, Foltz DR, Chakravarthy S, etal . Structural determinants for generating centromeric chromatin. . Nature . 430 . 6999 . 578–82 . 2004 . 15282608 . 10.1038/nature02766 . 2004Natur.430..578B . 4392941 .

Notes and References

1. Kardalinou E, Eick S, Albig W, Doenecke D . Association of a human H1 histone gene with an H2A pseudogene and genes encoding H2B.1 and H3.1 histones . . 52 . 4 . 375–83 . Dec 1993 . 8227173 . 10.1002/jcb.240520402 . 42454232 .
2. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D . Human histone gene organization: nonregular arrangement within a large cluster . . 40 . 2 . 314–22 . Apr 1997 . 9119399 . 10.1006/geno.1996.4592 .
3. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ . The human and mouse replication-dependent histone genes . Genomics . 80 . 5 . 487–98 . Oct 2002 . 12408966 . 10.1016/S0888-7543(02)96850-3 .
4. Web site: Entrez Gene: HIST1H3C histone cluster 1, H3c.
5. Web site: Entrez Gene: HIST1H3C histone cluster 1, H3c.