HIPK1 explained

Homeodomain-interacting protein kinase 1 is an enzyme that, in humans is encoded by the HIPK1 gene.^[1]

Function

The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.

Interactions

HIPK1 has been shown to interact with P53.^[2]

Further reading

• Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Research . 5 . 3 . 169–76 . Jun 1998 . 9734811 . 10.1093/dnares/5.3.169 . free .
• Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y . Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors . The Journal of Biological Chemistry . 273 . 40 . 25875–9 . Oct 1998 . 9748262 . 10.1074/jbc.273.40.25875 . free .
• Ecsedy JA, Michaelson JS, Leder P . Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity . Molecular and Cellular Biology . 23 . 3 . 950–60 . Feb 2003 . 12529400 . 140690 . 10.1128/MCB.23.3.950-960.2003 .
• Kondo S, Lu Y, Debbas M, Lin AW, Sarosi I, Itie A, Wakeham A, Tuan J, Saris C, Elliott G, Ma W, Benchimol S, Lowe SW, Mak TW, Thukral SK . Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1) . Proceedings of the National Academy of Sciences of the United States of America . 100 . 9 . 5431–6 . Apr 2003 . 12702766 . 154362 . 10.1073/pnas.0530308100 . 2003PNAS..100.5431K . free .
• Song JJ, Lee YJ . Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization . The Journal of Biological Chemistry . 278 . 47 . 47245–52 . Nov 2003 . 12968034 . 10.1074/jbc.M213201200 . free .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional proteomics mapping of a human signaling pathway . Genome Research . 14 . 7 . 1324–32 . Jul 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Li X, Zhang R, Luo D, Park SJ, Wang Q, Kim Y, Min W . Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation . The Journal of Biological Chemistry . 280 . 15 . 15061–70 . Apr 2005 . 15701637 . 10.1074/jbc.M414262200 . free .

Notes and References

1. Web site: Entrez Gene: HIPK1 homeodomain interacting protein kinase 1.
2. Kondo S, Lu Y, Debbas M, Lin AW, Sarosi I, Itie A, Wakeham A, Tuan J, Saris C, Elliott G, Ma W, Benchimol S, Lowe SW, Mak TW, Thukral SK . Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1) . Proceedings of the National Academy of Sciences of the United States of America . 100 . 9 . 5431–6 . Apr 2003 . 12702766 . 154362 . 10.1073/pnas.0530308100 . 2003PNAS..100.5431K . free .