HIC1 explained

Hypermethylated in cancer 1 protein is a protein that in humans is encoded by the HIC1 gene.^[1]

Further reading

• Chopin V, Leprince D . [Chromosome arm 17p13.3: could HIC1 be the one ?] . Med Sci (Paris) . 22 . 1 . 54–61 . 2006 . 16386221 . 10.1051/medsci/200622154 . free .
• Wales MM, Biel MA, el Deiry W, etal . p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. . Nat. Med. . 1 . 6 . 570–7 . 1995 . 7585125 . 10.1038/nm0695-570 . 21993943 .
• Fujii H, Biel MA, Zhou W, etal . Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer. . Oncogene . 16 . 16 . 2159–64 . 1998 . 9572497 . 10.1038/sj.onc.1201976 . free .
• Deltour S, Guerardel C, Stehelin D, Leprince D . The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved. . Biochim. Biophys. Acta . 1443 . 1–2 . 230–2 . 1999 . 9838134 . 10.1016/s0167-4781(98)00219-x.
• Deltour S, Guerardel C, Leprince D . Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B. . Proc. Natl. Acad. Sci. U.S.A. . 96 . 26 . 14831–6 . 2000 . 10611298 . 10.1073/pnas.96.26.14831 . 24733 . 1999PNAS...9614831D . free .
• Guerardel C, Deltour S, Pinte S, etal . Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53. . J. Biol. Chem. . 276 . 5 . 3078–89 . 2001 . 11073960 . 10.1074/jbc.M008690200 . free .
• Deltour S, Pinte S, Guérardel C, Leprince D . Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. . Biochem. Biophys. Res. Commun. . 287 . 2 . 427–34 . 2001 . 11554746 . 10.1006/bbrc.2001.5624 .
• Deltour S, Pinte S, Guerardel C, etal . The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif. . Mol. Cell. Biol. . 22 . 13 . 4890–901 . 2002 . 12052894 . 10.1128/MCB.22.13.4890-4901.2002 . 133903 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Cardoso C, Leventer RJ, Ward HL, etal . Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3. . Am. J. Hum. Genet. . 72 . 4 . 918–30 . 2003 . 12621583 . 10.1086/374320 . 1180354 .
• Rathi A, Virmani AK, Harada K, etal . Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms. . Clin. Cancer Res. . 9 . 10 Pt 1 . 3674–8 . 2004 . 14506157 .
• Waha A, Waha A, Koch A, etal . Epigenetic silencing of the HIC-1 gene in human medulloblastomas. . J. Neuropathol. Exp. Neurol. . 62 . 11 . 1192–201 . 2004 . 14656076 . 10.1093/jnen/62.11.1192. free .
• Lindsey JC, Lusher ME, Anderton JA, etal . Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling. . Carcinogenesis . 25 . 5 . 661–8 . 2004 . 14688019 . 10.1093/carcin/bgh055 . free .
• Pinte S, Guérardel C, Deltour-Balerdi S, etal . Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1. . Oncogene . 23 . 22 . 4023–31 . 2004 . 15007385 . 10.1038/sj.onc.1207504 . free .
• Pinte S, Stankovic-Valentin N, Deltour S, etal . The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties. . J. Biol. Chem. . 279 . 37 . 38313–24 . 2004 . 15231840 . 10.1074/jbc.M401610200 . free .
• Chen W, Cooper TK, Zahnow CA, etal . Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. . Cancer Cell . 6 . 4 . 387–98 . 2004 . 15488761 . 10.1016/j.ccr.2004.08.030 . free .
• Britschgi C, Rizzi M, Grob TJ, etal . Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1. . Oncogene . 25 . 14 . 2030–9 . 2006 . 16301995 . 10.1038/sj.onc.1209240 . 27624320 .
• Valenta T, Lukas J, Doubravska L, etal . HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. . EMBO J. . 25 . 11 . 2326–37 . 2006 . 16724116 . 10.1038/sj.emboj.7601147 . 1478201 .
• Stankovic-Valentin N, Verger A, Deltour-Balerdi S, etal . A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. . FEBS J. . 273 . 13 . 2879–90 . 2006 . 16762039 . 10.1111/j.1742-4658.2006.05301.x . 34249691 .

Notes and References

1. Web site: Entrez Gene: HIC1 hypermethylated in cancer 1.