3-hydroxyisobutyryl-CoA hydrolase explained

3-hydroxyisobutyryl-CoA hydrolase
Ec Number:	3.1.2.4
Cas Number:	9025-88-1
Go Code:	0003860
Width:	270

The enzyme 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) catalyzes the reaction

3-hydroxy-2-methylpropanoyl-CoA + H₂O

\rightleftharpoons CoA + 3-hydroxy-2-methylpropanoate

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is 3-hydroxy-2-methylpropanoyl-CoA hydrolase. Other names in common use include 3-hydroxy-isobutyryl CoA hydrolase, and HIB CoA deacylase. This enzyme participates in 3 metabolic pathways: valine, leucine and isoleucine degradation, β-alanine metabolism, and propanoate metabolism. 3-hydroxyisobutyryl-CoA hydrolase is encoded by HIBCH gene.^[1]

References

• Rendina G, Coon MJ . Enzymatic hydrolysis of the coenzyme A thiol esters of β-hydroxypropionic and β-hydroxyisobutyric acids . The Journal of Biological Chemistry . 225 . 1 . 523–34 . March 1957 . 13457352 .

Notes and References

1. Web site: OMIM Entry - * 610690 - 3-HYDROXYISOBUTYRYL-CoA HYDROLASE; HIBCH. www.omim.org. en-us. 2017-11-20.