HHIP explained

Hedgehog interacting protein (HHIP) is a protein that in humans is encoded by the HHIP gene.^{[1] [2] [3]}

This gene encodes a protein similar to the mouse hedgehog interacting protein, a regulatory component of the Hedgehog signaling pathway. Members of the hedgehog family are evolutionarily conserved proteins which are involved in many fundamental processes in embryonic development, including anteroposterior patterns of limbs and regulation of left-right asymmetry.^[3]

Further reading

• Chuang PT, McMahon AP . Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein . Nature . 397 . 6720 . 617–21 . 1999 . 10050855 . 10.1038/17611 . 1999Natur.397..617C . 204991314 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Clark HF, Gurney AL, Abaya E, etal . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Olsen CL, Hsu PP, Glienke J, etal . Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors . BMC Cancer . 4. 43 . 2004 . 15294024 . 10.1186/1471-2407-4-43 . 512291 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Kayed H, Kleeff J, Esposito I, etal . Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas . Mol. Carcinog. . 42 . 4 . 183–92 . 2005 . 15754313 . 10.1002/mc.20088 . 85407133 .
• Martin ST, Sato N, Dhara S, etal . Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms . Cancer Biol. Ther. . 4 . 7 . 728–33 . 2006 . 15970691 . 10.4161/cbt.4.7.1802. free .

Notes and References

1. Bak M, Hansen C, Friis Henriksen K, Tommerup N . The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21→q31.3 . Cytogenet Cell Genet . 92 . 3–4 . 300–3 . Jul 2001 . 11435703 . 10.1159/000056918 . 32938414 .
2. Ingham PW, McMahon AP . Hedgehog signaling in animal development: paradigms and principles . Genes Dev . 15 . 23 . 3059–87 . Dec 2001 . 11731473 . 10.1101/gad.938601 . free .
3. Web site: Entrez Gene: HHIP hedgehog interacting protein.