HEYL explained

Hairy/enhancer-of-split related with YRPW motif-like protein is a protein that in humans is encoded by the HEYL gene.^{[1] [2] [3]}

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.

Further reading

• Iso T, Kedes L, Hamamori Y . HES and HERP families: multiple effectors of the Notch signaling pathway. . J. Cell. Physiol. . 194 . 3 . 237–55 . 2003 . 12548545 . 10.1002/jcp.10208 . 6463286 .
• Kokubo H, Miyagawa-Tomita S, Johnson RL . Hesr, a mediator of the Notch signaling, functions in heart and vessel development. . Trends Cardiovasc. Med. . 15 . 5 . 190–4 . 2006 . 16165016 . 10.1016/j.tcm.2005.05.005 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Firulli BA, Hadzic DB, McDaid JR, Firulli AB . The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. . J. Biol. Chem. . 275 . 43 . 33567–73 . 2000 . 10924525 . 10.1074/jbc.M005888200 . 2561327 . free .
• Nakagawa O, McFadden DG, Nakagawa M, etal . Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 25 . 13655–60 . 2001 . 11095750 . 10.1073/pnas.250485597 . 17631 . free . 2000PNAS...9713655N .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Colland F, Jacq X, Trouplin V, etal . Functional proteomics mapping of a human signaling pathway. . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Leimeister C, Externbrink A, Klamt B, Gessler M . Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis . Mech Dev . 85 . 1–2 . 173–7 . Sep 1999 . 10415358 . 10.1016/S0925-4773(99)00080-5 . 17342136 .
2. Steidl C, Leimeister C, Klamt B, Maier M, Nanda I, Dixon M, Clarke R, Schmid M, Gessler M . Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family . Genomics . 66 . 2 . 195–203 . Aug 2000 . 10860664 . 10.1006/geno.2000.6200 .
3. Web site: Entrez Gene: HEYL hairy/enhancer-of-split related with YRPW motif-like.