HEXIM1 explained

Protein HEXIM1 is a protein that in humans is encoded by the HEXIM1 gene.^{[1] [2] [3]}

Interactions

HEXIM1 has been shown to interact with Cyclin T1 and Cdk9^[4]

Further reading

• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3491–6 . 2000 . 10737800 . 16267 . 10.1073/pnas.97.7.3491. 2000PNAS...97.3491D . free .
• Ouchida R, Kusuhara M, Shimizu N, Hisada T, Makino Y, Morimoto C, Handa H, Ohsuzu F, Tanaka H . Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells . Genes Cells . 8 . 2 . 95–107 . 2003 . 12581153 . 10.1046/j.1365-2443.2003.00618.x. 21478049 . free .
• Wittmann BM, Wang N, Montano MM . Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors . Cancer Res. . 63 . 16 . 5151–8 . 2003 . 12941847.
• Yik JH, Chen R, Nishimura R, Jennings JL, Link AJ, Zhou Q . Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA . Mol. Cell . 12 . 4 . 971–82 . 2003 . 14580347 . 10.1016/S1097-2765(03)00388-5. free .
• Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR . Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation . Cell . 117 . 3 . 311–21 . 2004 . 15109492 . 10.1016/S0092-8674(04)00342-3. 16049289 . free .
• Yik JH, Chen R, Pezda AC, Samford CS, Zhou Q . A Human Immunodeficiency Virus Type 1 Tat-Like Arginine-Rich RNA-Binding Domain Is Essential for HEXIM1 To Inhibit RNA Polymerase II Transcription through 7SK snRNA-Mediated Inactivation of P-TEFb . Mol. Cell. Biol. . 24 . 12 . 5094–105 . 2004 . 15169877 . 419863 . 10.1128/MCB.24.12.5094-5105.2004.
• Michels AA, Fraldi A, Li Q, Adamson TE, Bonnet F, Nguyen VT, Sedore SC, Price JP, Price DH, Lania L, Bensaude O . Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor . EMBO J. . 23 . 13 . 2608–19 . 2005 . 15201869 . 449783 . 10.1038/sj.emboj.7600275.
• Yik JH, Chen R, Pezda AC, Zhou Q . Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription . J. Biol. Chem. . 280 . 16 . 16368–76 . 2005 . 15713661 . 10.1074/jbc.M500912200 . free .
• Byers SA, Price JP, Cooper JJ, Li Q, Price DH . HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK . J. Biol. Chem. . 280 . 16 . 16360–7 . 2005 . 15713662 . 10.1074/jbc.M500424200. free .
• Schulte A, Czudnochowski N, Barboric M, Schönichen A, Blazek D, Peterlin BM, Geyer M . Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat . J. Biol. Chem. . 280 . 26 . 24968–77 . 2005 . 15855166 . 10.1074/jbc.M501431200. free .
• Wittmann BM, Fujinaga K, Deng H, Ogba N, Montano MM . The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1 . Oncogene . 24 . 36 . 5576–88 . 2005 . 15940264 . 10.1038/sj.onc.1208728. free .
• Shimizu N, Ouchida R, Yoshikawa N, Hisada T, Watanabe H, Okamoto K, Kusuhara M, Handa H, Morimoto C, Tanaka H . HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b . Proc. Natl. Acad. Sci. U.S.A. . 102 . 24 . 8555–60 . 2005 . 15941832 . 1150813 . 10.1073/pnas.0409863102. 2005PNAS..102.8555S . free .
• Li Q, Price JP, Byers SA, Cheng D, Peng J, Price DH . Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186 . J. Biol. Chem. . 280 . 31 . 28819–26 . 2005 . 15965233 . 10.1074/jbc.M502712200. free .
• Fraldi A, Varrone F, Napolitano G, Michels AA, Majello B, Bensaude O, Lania L . Inhibition of Tat activity by the HEXIM1 protein . Retrovirology . 2 . 42 . 2006 . 15992410 . 1183248 . 10.1186/1742-4690-2-42 . free .
• Dulac C, Michels AA, Fraldi A, Bonnet F, Nguyen VT, Napolitano G, Lania L, Bensaude O . Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer . J. Biol. Chem. . 280 . 34 . 30619–29 . 2005 . 15994294 . 10.1074/jbc.M502471200. free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209. 2005Natur.437.1173R . 4427026 .

Notes and References

1. Huang F, Wagner M, Siddiqui MA . Structure, expression, and functional characterization of the mouse CLP-1 gene . Gene . 292 . 1–2 . 245–59 . Jul 2002 . 12119119 . 10.1016/S0378-1119(02)00596-6 .
2. Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, Lania L, Bensaude O . MAQ1 and 7SK RNA Interact with CDK9/Cyclin T Complexes in a Transcription-Dependent Manner . Mol Cell Biol . 23 . 14 . 4859–69 . Jun 2003 . 12832472 . 162212 . 10.1128/MCB.23.14.4859-4869.2003 .
3. Web site: Entrez Gene: HEXIM1 hexamethylene bis-acetamide inducible 1.
4. Kobbi L, Demey-Thomas E, Braye F, Proux F, Kolesnikova O, Vinh J, Poterszman A, Bensaude O . An evolutionary conserved Hexim1 peptide binds to the Cdk9 catalytic site to inhibit P-TEFb . Proc Natl Acad Sci U S A . 113 . 45 . 12721–6 . October 2016 . 27791144 . 5111705 . 10.1073/pnas.1612331113. 2016PNAS..11312721K . free .