HERC3 explained
| HERC3 |
| Symbol: | HERC3 |
| Altnames: | HECT domain and RCC1-like domain-containing protein 3, HECT-type E3 ubiquitin transferase HERC3, KIAA0032 |
| Width: | 150 px |
| Entrezgene: | 8916 |
| Hgncid: | 4876 |
| Omim: | 605200 |
| Pdb: | Q15034 |
| Refseq: | NM_014606, NM_001271602, NM_001318505 |
| Uniprot: | Q15034 |
| Ecnumber: | 2.3.2.26 |
| Chromosome: | 4 |
| Arm: | q |
| Band: | 22.1 |
| Locussupplementarydata: | 88,592,422-88,709,302
|
Probable E3 ubiquitin-protein ligase HERC3 is an enzyme that in humans is encoded by the HERC3 gene.[1] [2] The gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and an RCC1-like domain (RLD). It binds ubiquitin and hPLIC-1/2 via its HECT domain. Alternatively spiced transcript variants encoding multiple isoforms have been observed, and mutations in this gene have been linked to colorectal and gastric carcinomas. The protein is localized in the cytosol and vesicular-like structures containing β-COP, ARF, and Rab5. Since HERC3 can itself be ubiquitinated and degraded by the proteasome, it likely has roles in both vesicular traffic and ubiquitin-dependent processes.[3] [4] [5]
Further reading
- Hochrainer K, Pejanovic N, Olaseun VA, Zhang S, Iadecola C, Anrather J . The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation . Nucleic Acids Res . 43 . 20 . 9889–9904 . 16 Nov 2015 . 4787756 . 10.1093/nar/gkv1064 . 26476452 .
- Cowley M, Wood AJ, Böhm S, Schulz R, Oakey RJ . Epigenetic control of alternative mRNA processing at the imprinted Herc3/Nap1l5 locus . Nucleic Acids Res . 40 . 18 . 8917–8926 . Oct 2012 . 3467052 . 10.1093/nar/gks654 . 22790983 .
- Yoo NJ, Park SJ, Lee SH . Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability . Pathology . 43 . 7 . 753–755 . Dec 2011 . 22124266 . 10.1097/PAT.0b013e32834c7e78 .
- Scheffner M, Staub O . HECT E3s and human disease . BMC Biochem . 8 . (Suppl 1):S6 . S6. 22 Nov 2007 . 10.1186/1471-2091-8-S1-S6 . 2106370 . 18047743 . free .
- Cruz C, Nadal M, Ventura F, Bartrons R, Estivill X, Rosa JL . The human HERC3 gene maps to chromosome 4q21 by fluorescence in situ hybridization . Cytogenet Cell Genet . 87 . 3–4 . 263–264 . 1999 . 10702688 . 10.1159/000015442 . 42602080 .
Notes and References
- Garcia-Gonzalo FR, Rosa JL . The HERC proteins: functional and evolutionary insights . Cell Mol Life Sci . 62 . 16 . 1826–1838 . Aug 2005 . 10.1007/s00018-005-5119-y . 15968461. 23391275 . 11139159 .
- Sánchez-Tena S, Cubillos-Rojas M, Schneider T, Rosa JL . Functional and pathological relevance of HERC family proteins: a decade later . Cell Mol Life Sci . 73 . 10 . 18955–1968 . May 2016 . 10.1007/s00018-016-2139-8 . 26801221. 7457614 . 11108380 .
- Hochrainer K, Kroismayr R, Baranyi U, Binder BR, Lipp J . Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B . Cell Mol Life Sci . 65 . 13 . 2105–2117 . Jul 2008 . 10.1007/s00018-008-8148-5 . 18535780. 6897759 . 11131906 .
- Cruz C, Ventura F, Bartrons R, Rosa JL . HERC3 binding to and regulation by ubiquitin . FEBS Lett . 488 . 1–2 . 74–80 . Jan 2001 . 11163799. 10.1016/S0014-5793(00)02371-1 . 20091003 . free .
- Web site: Entrez Gene: HERC3 .
