HEPPS (buffer) explained

HEPPS (EPPS) is a buffering agent used in biology and biochemistry. The pKa of HEPPS is 8.00. It is ones of Good's buffers.^[1]

Research on mice with Alzheimer's disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice.^{[2] [3] [4]} HEPPS was reported to dissociate amyloid beta oligomers in patients' plasma samples enabling blood diagnosis of Alzheimer's disease.^{[5] [6] [7]}

See also

• CAPSO
• CHES
• HEPES

Notes and References

1. 5942950. 1966. Good. N. E. Hydrogen ion buffers for biological research. Biochemistry. 5. 2. 467–77. Winget. G. D. Winter. W. Connolly. T. N. Izawa. S. Singh. R. M. 10.1021/bi00866a011.
2. Small Molecule Breaks Up Amyloid Aggregates In Mice . . 14 December 2015.
3. Kim. Hye Yun. Kim. Hyunjin Vincent. Jo. Seonmi. Lee. C. Justin. Choi. Seon Young. Kim. Dong Jin. Kim. YoungSoo. EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques. Nature Communications. 8 December 2015. 6. 8997. 10.1038/ncomms9997. 26646366. 4686862. 2015NatCo...6.8997K.
4. Web site: Chemical clears Alzheimer's protein and restores memory in mice . MedicalXpress . December 10, 2015.
5. Kim. YoungSoo. Yoo. Yong Kyoung. Kim. Hye Yun. Roh. Jee Hoon. Kim. Jinsik. Baek. Seungyeop. Lee. Jinny Claire. Kim. Hye Jin. Chae. Myung-Sic. Jeong. Dahye. Park. Dongsung. 2019-04-01. Comparative analyses of plasma amyloid-β levels in heterogeneous and monomerized states by interdigitated microelectrode sensor system. Science Advances. en. 5. 4. eaav1388. 10.1126/sciadv.aav1388. 31001580. 6469948. 2019SciA....5.1388K. 2375-2548. free.
6. Web site: Blood Test for Detecting Pre-symptomatic Alzheimer's Disease is Refined. Analysis & Separations from Technology Networks. en. 2019-09-30.
7. Web site: A possible blood test for early-stage Alzheimer's disease. medicalxpress.com. en-us. 2019-09-30.