HEPN1 explained
Hepatocellular carcinoma, down-regulated 1 is a protein that in humans is encoded by the HEPN1 gene.[1]
Function
This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm. Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it may have a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes.[2] Also to note is that this gene maps to the 3'-noncoding region of the HEPACAM gene (GeneID:220296) on the antisense strand.[3]
Further reading
- Kim HS, Jung G . Reactive oxygen species increase HEPN1 expression via activation of the XBP1 transcription factor . FEBS Lett. . 588 . 23 . 4413–21 . 2014 . 25448679 . 10.1016/j.febslet.2014.10.011 . 859229 . free .
Notes and References
- Web site: Entrez Gene: Hepatocellular carcinoma, down-regulated 1. 2017-09-12.
- 12971969 . 39 . 4 . HEPN1, a novel gene that is frequently down-regulated in hepatocellular carcinoma, suppresses cell growth and induces apoptosis in HepG2 cells . 2003 . J Hepatol . 580–6 . Moh MC, Lee LH, Yang X, Shen S . 10.1016/s0168-8278(03)00359-3.
- 15885354 . 10.1016/j.jhep.2005.01.025 . 42 . 6 . Cloning and characterization of hepaCAM, a novel Ig-like cell adhesion molecule suppressed in human hepatocellular carcinoma . 2005 . J Hepatol . 833–41 . Chung Moh M, Hoon Lee L, Shen S.
