HEMGN explained
Hemogen is a protein that in humans is encoded by the HEMGN gene.[1]
Further reading
- Yang LV, Nicholson RH, Kaplan J, etal . Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic development and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms. . Mech. Dev. . 104 . 1–2 . 105–11 . 2001 . 11404085 . 10.1016/S0925-4773(01)00376-8 . 2968450 .
- Yu Y, Zhang C, Zhou G, etal . Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs . Genome Res. . 11 . 8 . 1392–403 . 2001 . 11483580 . 10.1101/gr.175501 . 311073 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Yang LV, Heng HH, Wan J, etal . Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis . Dev. Dyn. . 228 . 4 . 606–16 . 2004 . 14648837 . 10.1002/dvdy.10399 . 26030697 . free .
- Liu CC, Chou YL, Ch'ang LY . Down-regulation of human NDR gene in megakaryocytic differentiation of erythroleukemia K562 cells . J. Biomed. Sci. . 11 . 1 . 104–16 . 2004 . 14730214 . 10.1159/000075293 . 202650770 .
- Humphray SJ, Oliver K, Hunt AR, etal . DNA sequence and analysis of human chromosome 9 . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . 2004Natur.429..369H .
- Li CY, Zhan YQ, Xu CW, etal . EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-kappa B . Cell Death Differ. . 11 . 12 . 1299–308 . 2005 . 15332117 . 10.1038/sj.cdd.4401490 . free .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- An LL, Li G, Wu KF, etal . High expression of EDAG and its significance in AML . Leukemia . 19 . 8 . 1499–502 . 2005 . 15920494 . 10.1038/sj.leu.2403808 . 5280303 .
- Yang LV, Wan J, Ge Y, etal . The GATA site-dependent hemogen promoter is transcriptionally regulated by GATA1 in hematopoietic and leukemia cells . Leukemia . 20 . 3 . 417–25 . 2006 . 16437149 . 10.1038/sj.leu.2404105 . 9613437 .
- Ling B, Zhou Y, Feng D, etal . Down-regulation of EDAG expression by retrovirus-mediated small interfering RNA inhibits the growth and IL-8 production of leukemia cells . Oncol. Rep. . 18 . 3 . 659–64 . 2007 . 17671716 . 10.3892/or.18.3.659. free .
Notes and References
- Web site: Entrez Gene: HEMGN hemogen.