HECW1 explained

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 is a protein that in humans is encoded by the HECW1 gene.^[1] In human it has 1606 amino acids (179.5 kDa) and isoelectric point of 5.18.^[2]

Further reading

• Miyazaki K, Fujita T, Ozaki T, Kato C, Kurose Y, Sakamoto M, Kato S, Goto T, Itoyama Y, Aoki M, Nakagawara A . NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1 . The Journal of Biological Chemistry . 279 . 12 . 11327–35 . March 2004 . 14684739 . 10.1074/jbc.M312389200 . free .
• Chansard M, Wang J, Tran HC, Neumayer G, Shim SY, Park YU, Belzil C, Le HT, Park SK, Nguyen MD . The cytoskeletal protein Ndel1 regulates dynamin 2 GTPase activity . PLOS ONE . 6 . 1 . e14583 . January 2011 . 21283621 . 3026782 . 10.1371/journal.pone.0014583 . 2011PLoSO...614583C . free .
• Sherva R, Tripodis Y, Bennett DA, Chibnik LB, Crane PK, de Jager PL, Farrer LA, Saykin AJ, Shulman JM, Naj A, Green RC . Genome-wide association study of the rate of cognitive decline in Alzheimer's disease . Alzheimer's & Dementia . 10 . 1 . 45–52 . January 2014 . 23535033 . 3760995 . 10.1016/j.jalz.2013.01.008 . Alzheimer's Disease Neuroimaging Initiative . Alzheimer's Disease Genetics Consortium .
• Li Y, Ozaki T, Kikuchi H, Yamamoto H, Ohira M, Nakagawara A . A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner . Oncogene . 27 . 26 . 3700–9 . June 2008 . 18223681 . 10.1038/sj.onc.1211032 . free .
• Harvey KF, Dinudom A, Cook DI, Kumar S . The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel . The Journal of Biological Chemistry . 276 . 11 . 8597–601 . March 2001 . 11244092 . 10.1074/jbc.C000906200 . free .
• Zhang L, Haraguchi S, Koda T, Hashimoto K, Nakagawara A . Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice . Journal of Biomedicine & Biotechnology . 2011 . 1–7 . 2011 . 20976258 . 2952905 . 10.1155/2011/831092 . free .
• Cui Y, He S, Xing C, Lu K, Wang J, Xing G, Meng A, Jia S, He F, Zhang L . SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1 . The EMBO Journal . 30 . 13 . 2675–89 . May 2011 . 21572392 . 3155294 . 10.1038/emboj.2011.155 .
• Shinada K, Tsukiyama T, Sho T, Okumura F, Asaka M, Hatakeyama S . RNF43 interacts with NEDL1 and regulates p53-mediated transcription . Biochemical and Biophysical Research Communications . 404 . 1 . 143–7 . January 2011 . 21108931 . 10.1016/j.bbrc.2010.11.082 . 2115/44929 . 8665279 . free .
• Levine DM, Ek WE, Zhang R, Liu X, Onstad L, Sather C, Lao-Sirieix P, Gammon MD, Corley DA, Shaheen NJ, Bird NC, Hardie LJ, Murray LJ, Reid BJ, Chow WH, Risch HA, Nyrén O, Ye W, Liu G, Romero Y, Bernstein L, Wu AH, Casson AG, Chanock SJ, Harrington P, Caldas I, Debiram-Beecham I, Caldas C, Hayward NK, Pharoah PD, Fitzgerald RC, Macgregor S, Whiteman DC, Vaughan TL . A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus . Nature Genetics . 45 . 12 . 1487–93 . December 2013 . 24121790 . 3840115 . 10.1038/ng.2796 .

Notes and References

1. Web site: Entrez Gene: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 .
2. Kozlowski LP . IPC - Isoelectric Point Calculator . Biology Direct . 11 . 1 . 55 . October 2016 . 27769290 . 10.1186/s13062-016-0159-9 . 5075173 . free .