HEBP1 explained

Heme binding protein 1 is a protein that in humans is encoded by the HEBP1 gene.^[1]

Function

The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells.^[1]

Further reading

• Jacob Blackmon B, Dailey TA, Lianchun X, Dailey HA . Characterization of a human and mouse tetrapyrrole-binding protein . Archives of Biochemistry and Biophysics . 407 . 2 . 196–201 . Nov 2002 . 12413491 . 10.1016/s0003-9861(02)00471-x.
• Gao JL, Guillabert A, Hu J, Le Y, Urizar E, Seligman E, Fang KJ, Yuan X, Imbault V, Communi D, Wang JM, Parmentier M, Murphy PM, Migeotte I . F2L, a peptide derived from heme-binding protein, chemoattracts mouse neutrophils by specifically activating Fpr2, the low-affinity N-formylpeptide receptor . Journal of Immunology . 178 . 3 . 1450–6 . Feb 2007 . 17237393 . 10.4049/jimmunol.178.3.1450. free .
• Micaelo NM, Macedo AL, Goodfellow BJ, Félix V . Tetrapyrrole binding affinity of the murine and human p22HBP heme-binding proteins . Journal of Molecular Graphics & Modelling . 29 . 3 . 396–405 . Nov 2010 . 20800521 . 10.1016/j.jmgm.2010.07.008 .
• Migeotte I, Riboldi E, Franssen JD, Grégoire F, Loison C, Wittamer V, Detheux M, Robberecht P, Costagliola S, Vassart G, Sozzani S, Parmentier M, Communi D . Identification and characterization of an endogenous chemotactic ligand specific for FPRL2 . The Journal of Experimental Medicine . 201 . 1 . 83–93 . Jan 2005 . 15623572 . 2212760 . 10.1084/jem.20041277 .
• Devosse T, Dutoit R, Migeotte I, De Nadai P, Imbault V, Communi D, Salmon I, Parmentier M . Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3 . Journal of Immunology . 187 . 3 . 1475–85 . Aug 2011 . 21709160 . 10.4049/jimmunol.1003545 . free .
• Zylka MJ, Reppert SM . Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches . Brain Research. Molecular Brain Research . 74 . 1–2 . 175–81 . Dec 1999 . 10640688 . 10.1016/s0169-328x(99)00277-6.

Notes and References

1. Web site: Entrez Gene: Heme binding protein 1 .