Hepatoma-derived growth factor explained

Hepatoma-derived growth factor (HDGF) also known as high mobility group protein 1-like 2 (HMG-1L2) is a protein that in humans is encoded by the HDGF gene.^{[1] [2]}

Further reading

• Everett AD, Bushweller J . Hepatoma derived growth factor is a nuclear targeted mitogen. . Current Drug Targets . 4 . 5 . 367–71 . 2003 . 12816346 . 10.2174/1389450033490975 .
• Nakamura H, Izumoto Y, Kambe H, etal . Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. Its homology with high mobility group-1 protein. . J. Biol. Chem. . 269 . 40 . 25143–9 . 1994 . 10.1016/S0021-9258(17)31509-0 . 7929202 . free .
• Kishima Y, Yamamoto H, Izumoto Y, etal . Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus by nuclear localization signals. . J. Biol. Chem. . 277 . 12 . 10315–22 . 2002 . 11751870 . 10.1074/jbc.M111122200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Mori M, Morishita H, Nakamura H, etal . Hepatoma-derived growth factor is involved in lung remodeling by stimulating epithelial growth. . Am. J. Respir. Cell Mol. Biol. . 30 . 4 . 459–69 . 2004 . 12972397 . 10.1165/rcmb.2003-0013OC .
• Yoshida K, Nakamura H, Okuda Y, etal . Expression of hepatoma-derived growth factor in hepatocarcinogenesis. . J. Gastroenterol. Hepatol. . 18 . 11 . 1293–301 . 2004 . 14535987 . 10.1046/j.1440-1746.2003.03191.x . 24881855 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Shu H, Chen S, Bi Q, etal . Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line. . Mol. Cell. Proteomics . 3 . 3 . 279–86 . 2004 . 14729942 . 10.1074/mcp.D300003-MCP200 . free .
• Everett AD, Narron JV, Stoops T, etal . Hepatoma-derived growth factor is a pulmonary endothelial cell-expressed angiogenic factor. . Am. J. Physiol. Lung Cell Mol. Physiol. . 286 . 6 . L1194–201 . 2004 . 14751852 . 10.1152/ajplung.00427.2003 . 17651256 .
• Sue SC, Chen JY, Huang TH . Sequence specific 1H, 13C and 15N resonance assignments of the hath-domain of human hepatoma-derived growth factor. . J. Biomol. NMR . 29 . 1 . 95–6 . 2004 . 15017145 . 10.1023/B:JNMR.0000019467.57276.05 . 84545598 .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Ballif BA, Villén J, Beausoleil SA, etal . Phosphoproteomic analysis of the developing mouse brain. . Mol. Cell. Proteomics . 3 . 11 . 1093–101 . 2005 . 15345747 . 10.1074/mcp.M400085-MCP200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Shen XY, Zacal N, Singh G, Rainbow AJ . Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells. . Photochem. Photobiol. . 81 . 2 . 306–13 . 2005 . 15560738 . 10.1562/2004-07-22-RA-242 .
• Barrios-Rodiles M, Brown KR, Ozdamar B, etal . High-throughput mapping of a dynamic signaling network in mammalian cells. . Science . 307 . 5715 . 1621–5 . 2005 . 15761153 . 10.1126/science.1105776 . 2005Sci...307.1621B . 39457788 .
• Iwasaki T, Nakagawa K, Nakamura H, etal . Hepatoma-derived growth factor as a prognostic marker in completely resected non-small-cell lung cancer. . Oncol. Rep. . 13 . 6 . 1075–80 . 2005 . 15870924 . 10.3892/or.13.6.1075.
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F . Phosphoproteomic analysis of the human pituitary. . Pituitary . 9 . 2 . 109–20 . 2006. 16807684 . 10.1007/s11102-006-8916-x . 10789246 .
• Clermont F, Gonzalez NS, Communi D, Franken S, Dumont JE, Robaye B . HDGF is dephosphorylated during the early steps of endothelial cell apoptosis in a caspase-dependent way. . J Cell Biochem . 104 . 4 . 1161–1171 . 2008 . 18465786 . 10.1002/jcb.21788 . 8154321 .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Hepatoma-derived growth factor

Notes and References

1. Wanschura S, Schoenmakers EF, Huysmans C, Bartnitzke S, Van de Ven WJ, Bullerdiek J . Mapping of the gene encoding the human hepatoma-derived growth factor (HDGF) with homology to the high-mobility group (HMG)-1 protein to Xq25 . Genomics . 32 . 2 . 298–300 . May 1997 . 8833162 . 10.1006/geno.1996.0122 .
2. Web site: Entrez Gene: HDGF hepatoma-derived growth factor (high-mobility group protein 1-like).