HCN3 explained

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 is a protein that in humans is encoded by the HCN3 gene.^{[1] [2]}

See also

• Cyclic nucleotide-gated ion channel

Further reading

• Santoro B, Grant SG, Bartsch D, Kandel ER . Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. . Proc. Natl. Acad. Sci. U.S.A. . 94 . 26 . 14815–20 . 1998 . 9405696 . 10.1073/pnas.94.26.14815 . 25120 . free . 1997PNAS...9414815S .
• Ludwig A, Zong X, Jeglitsch M, etal . A family of hyperpolarization-activated mammalian cation channels. . Nature . 393 . 6685 . 587–91 . 1998 . 9634236 . 10.1038/31255 . 1998Natur.393..587L . 4429453 .
• Nagase T, Kikuno R, Ishikawa K, etal . Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 7 . 2 . 143–50 . 2000 . 10819331 . 10.1093/dnares/7.2.143 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Much B, Wahl-Schott C, Zong X, etal . Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels. . J. Biol. Chem. . 278 . 44 . 43781–6 . 2003 . 12928435 . 10.1074/jbc.M306958200 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Stieber J, Stöckl G, Herrmann S, etal . Functional expression of the human HCN3 channel. . J. Biol. Chem. . 280 . 41 . 34635–43 . 2005 . 16043489 . 10.1074/jbc.M502508200 . free .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .

Notes and References

1. Hofmann F, Biel M, Kaupp UB . International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels . Pharmacol Rev . 57 . 4 . 455–62 . Dec 2005 . 16382102 . 10.1124/pr.57.4.8 . 45853869 .
2. Web site: Entrez Gene: HCN3 hyperpolarization activated cyclic nucleotide-gated potassium channel 3.