HCLS1 explained

Hematopoietic lineage cell-specific protein is a protein that in humans is encoded by the HCLS1 gene.^{[1] [2] [3]}

Interactions

HCLS1 has been shown to interact with Caspase 3.^{[4] [5]}

Further reading

• Kitamura D, Kaneko H, Miyagoe Y, etal . Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage. . Nucleic Acids Res. . 17 . 22 . 9367–79 . 1990 . 2587259 . 335138 .
• Yamanashi Y, Okada M, Semba T, etal . Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling. . Proc. Natl. Acad. Sci. U.S.A. . 90 . 8 . 3631–5 . 1993 . 7682714 . 10.1073/pnas.90.8.3631. 46355 . 1993PNAS...90.3631Y . free .
• Hata D, Nakamura T, Kawakami T, etal . Tyrosine phosphorylation of MB-1, B29, and HS1 proteins in human B cells following receptor crosslinking. . Immunol. Lett. . 40 . 1 . 65–71 . 1994 . 7927516 . 10.1016/0165-2478(94)90208-9 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Egerton M, Moritz RL, Druker B, etal . Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes. . Biochem. Biophys. Res. Commun. . 224 . 3 . 666–74 . 1996 . 8713105 . 10.1006/bbrc.1996.1082 .
• Suzuki Y, Demoliere C, Kitamura D, etal . HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases. . J. Immunol. . 158 . 6 . 2736–44 . 1997 . 10.4049/jimmunol.158.6.2736 . 9058808 . 25584050 . free .
• Yamanashi Y, Fukuda T, Nishizumi H, etal . Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis. . J. Exp. Med. . 185 . 7 . 1387–92 . 1997 . 9104825 . 10.1084/jem.185.7.1387. 2196252 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Brunati AM, Donella-Deana A, James P, etal . Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase. . J. Biol. Chem. . 274 . 11 . 7557–64 . 1999 . 10066823 . 10.1074/jbc.274.11.7557 . free .
• Nagata Y, Kiefer F, Watanabe T, Todokoro K . Activation of hematopoietic progenitor kinase-1 by erythropoietin. . Blood . 93 . 10 . 3347–54 . 1999 . 10233887 . 10.1182/blood.V93.10.3347.410k06_3347_3354.
• Takemoto Y, Furuta M, Sato M, etal . Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3. . Int. Immunol. . 11 . 12 . 1957–64 . 2000 . 10590261 . 10.1093/intimm/11.12.1957 . free .
• Ruzzene M, Brunati AM, Sarno S, etal . Ser/Thr phosphorylation of hematopoietic specific protein 1 (HS1): implication of protein kinase CK2. . Eur. J. Biochem. . 267 . 10 . 3065–72 . 2000 . 10806407 . 10.1046/j.1432-1033.2000.01333.x .
• Chen YR, Kori R, John B, Tan TH . Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis. . Biochem. Biophys. Res. Commun. . 288 . 4 . 981–9 . 2001 . 11689006 . 10.1006/bbrc.2001.5862 .
• Ruzzene M, Penzo D, Pinna LA . Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells. . Biochem. J. . 364 . Pt 1 . 41–7 . 2002 . 11988074 . 10.1042/bj3640041. 1222543 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Salomon AR, Ficarro SB, Brill LM, etal . Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. . Proc. Natl. Acad. Sci. U.S.A. . 100 . 2 . 443–8 . 2003 . 12522270 . 10.1073/pnas.2436191100 . 141014 . 2003PNAS..100..443S . free .
• Uruno T, Zhang P, Liu J, etal . Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin polymerization. . Biochem. J. . 371 . Pt 2 . 485–93 . 2003 . 12534372 . 10.1042/BJ20021791 . 1223309 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Brill LM, Salomon AR, Ficarro SB, etal . Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. . Anal. Chem. . 76 . 10 . 2763–72 . 2004 . 15144186 . 10.1021/ac035352d .

Notes and References

1. Egashira M, Kitamura D, Watanabe T, Niikawa N . The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization . Cytogenet Cell Genet . 72 . 2–3 . 175–6 . Jan 1997 . 8978766 . 10.1159/000134179 .
2. van Rossum AG, Schuuring-Scholtes E, van Buuren-van Seggelen V, Kluin PM, Schuuring E . Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain . BMC Genomics . 6 . 15 . Mar 2005 . 15710041 . 554100 . 10.1186/1471-2164-6-15 . free .
3. Web site: Entrez Gene: HCLS1 hematopoietic cell-specific Lyn substrate 1.
4. Ruzzene . Maria . Penzo Daniele . Pinna Lorenzo A . May 2002 . Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells . Biochem. J. . 364 . Pt 1 . 41–7 . England. 0264-6021. 11988074 . 1222543 . 10.1042/bj3640041.
5. Chen . Y R . Kori R . John B . Tan T H . Nov 2001 . Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis . Biochem. Biophys. Res. Commun. . 288 . 4 . 981–9 . United States. 0006-291X. 11689006 . 10.1006/bbrc.2001.5862 .