HBQ1 explained

Hemoglobin subunit theta-1 is a protein that in humans is encoded by the HBQ1 gene.^{[1] [2]}

Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue.^[3]

Further reading

• Giardina B, Messana I, Scatena R, Castagnola M . The multiple functions of hemoglobin. . Crit. Rev. Biochem. Mol. Biol. . 30 . 3 . 165–96 . 1995 . 7555018 . 10.3109/10409239509085142 .
• Kim JH, Yu CY, Bailey A, etal . Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters. . Nucleic Acids Res. . 17 . 14 . 5687–700 . 1989 . 2569721 . 10.1093/nar/17.14.5687 . 318189 .
• Ley TJ, Maloney KA, Gordon JI, Schwartz AL . Globin gene expression in erythroid human fetal liver cells. . J. Clin. Invest. . 83 . 3 . 1032–8 . 1989 . 2921315 . 10.1172/JCI113944 . 303780 .
• Gonzalez-Redondo JM, Han IS, Gu YC, Huisman TH . Nucleotide sequence of the human theta 1-globin gene. . Biochem. Genet. . 26 . 3–4 . 207–11 . 1988 . 3408475 . 10.1007/BF00561460 . 19352648 .
• Hsu SL, Marks J, Shaw JP, etal . Structure and expression of the human theta 1 globin gene . Nature . 331 . 6151 . 94–6 . 1988 . 3422341 . 10.1038/331094a0 . 1988Natur.331...94H . 4357357 .
• Daniels RJ, Peden JF, Lloyd C, etal . Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 . Hum. Mol. Genet. . 10 . 4 . 339–52 . 2001 . 11157797 . 10.1093/hmg/10.4.339 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• De Gobbi M, Viprakasit V, Hughes JR, etal . A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter . Science . 312 . 5777 . 1215–7 . 2006 . 16728641 . 10.1126/science.1126431 . 2006Sci...312.1215D . 16044469 .

Notes and References

1. Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ . A review of the molecular genetics of the human alpha-globin gene cluster . Blood . 73 . 5 . 1081–104 . May 1989 . 2649166 . 10.1182/blood.V73.5.1081.1081. free .
2. Web site: Entrez Gene: HBQ1 hemoglobin, theta 1.
3. Web site: Entrez Gene: HBQ1 hemoglobin, theta 1.