HAS3 explained

Hyaluronan synthase 3 is an enzyme that in humans is encoded by the HAS3 gene.^{[1] [2] [3]}

The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Jacobson A, Brinck J, Briskin MJ, etal . Expression of human hyaluronan synthases in response to external stimuli. . 348 . Biochem. J. . Pt 1 . 1. 29–35 . 2000 . 10794710 . 10.1042/0264-6021:3480029 . 1221032 .
• Simpson MA, Reiland J, Burger SR, etal . Hyaluronan synthase elevation in metastatic prostate carcinoma cells correlates with hyaluronan surface retention, a prerequisite for rapid adhesion to bone marrow endothelial cells. . J. Biol. Chem. . 276 . 21 . 17949–57 . 2001 . 11278609 . 10.1074/jbc.M010064200 . free .
• Kuroda K, Utani A, Hamasaki Y, Shinkai H . Up-regulation of putative hyaluronan synthase mRNA by basic fibroblast growth factor and insulin-like growth factor-1 in human skin fibroblasts. . J. Dermatol. Sci. . 26 . 2 . 156–60 . 2001 . 11378333 . 10.1016/S0923-1811(00)00155-9 .
• Liu N, Gao F, Han Z, etal . Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells. . Cancer Res. . 61 . 13 . 5207–14 . 2001 . 11431361 .
• Simpson MA, Wilson CM, Furcht LT, etal . Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells. . J. Biol. Chem. . 277 . 12 . 10050–7 . 2002 . 11790779 . 10.1074/jbc.M110069200 . free .
• Sayo T, Sugiyama Y, Takahashi Y, etal . Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes. . J. Invest. Dermatol. . 118 . 1 . 43–8 . 2002 . 11851874 . 10.1046/j.0022-202x.2001.01613.x . free .
• Chagnon P, Michaud J, Mitchell G, etal . A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis. . Am. J. Hum. Genet. . 71 . 6 . 1443–9 . 2003 . 12417987 . 10.1086/344580 . 378590 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Bullard KM, Kim HR, Wheeler MA, etal . Hyaluronan synthase-3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth. . Int. J. Cancer . 107 . 5 . 739–46 . 2004 . 14566823 . 10.1002/ijc.11475 . 24405794 . free .
• Suzuki K, Yamamoto T, Usui T, etal . Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta. . Jpn. J. Ophthalmol. . 47 . 6 . 557–64 . 2004 . 14636845 . 10.1016/j.jjo.2003.09.001 .
• Grskovic B, Pollaschek C, Mueller MM, Stuhlmeier KM . Expression of hyaluronan synthase genes in umbilical cord blood stem/progenitor cells. . Biochim. Biophys. Acta . 1760 . 6 . 890–5 . 2006 . 16564133 . 10.1016/j.bbagen.2006.02.002 .
• Campo GM, Avenoso A, Campo S, etal . TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate. . Mol. Cell. Biochem. . 292 . 1–2 . 169–78 . 2007 . 16786194 . 10.1007/s11010-006-9230-7 . 37598580 .

Notes and References

1. Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA . Chromosomal localization of the human and mouse hyaluronan synthase genes . Genomics . 41 . 3 . 493–7 . Jul 1997 . 9169154 . 10.1006/geno.1997.4696 .
2. Spicer AP, Olson JS, McDonald JA . Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase . J Biol Chem . 272 . 14 . 8957–61 . May 1997 . 9083017 . 10.1074/jbc.272.14.8957 . free .
3. Web site: Entrez Gene: HAS3 hyaluronan synthase 3.