HAGH explained

Hydroxyacylglutathione hydrolase, mitochondrial is an enzyme that in humans is encoded by the HAGH gene.^{[1] [2] [3]}

The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate.

Further reading

• Kar NC, Pearson CM . Glyoxalase enzyme system in human muscular dystrophy . Clin. Chim. Acta . 65 . 1 . 153–5 . 1976 . 1192606 . 10.1016/0009-8981(75)90348-4 .
• Hamilton DS, Creighton DJ . Inhibition of glyoxalase I by the enediol mimic S-(N-hydroxy-N-methylcarbamoyl)glutathione. The possible basis of a tumor-selective anticancer strategy . J. Biol. Chem. . 267 . 35 . 24933–6 . 1993 . 10.1016/S0021-9258(19)73986-6 . 1459997 . free .
• Mulley JC, Barton N, Callen DF . Localisation of human PGP and HAGH genes to 16p13.3 . Cytogenet. Cell Genet. . 53 . 2–3 . 175–6 . 1990 . 2164460 . 10.1159/000132923 .
• Talesa V . Demonstration of glyoxalase II in rat liver mitochondria. Partial purification and occurrence in multiple forms . Biochim. Biophys. Acta . 955 . 1 . 103–10 . 1988 . 3382669 . 10.1016/0167-4838(88)90183-5 . vanc. Uotila L . Koivusalo M . 3 . Principato . G . Giovannini . E . Rosi . G .
• Thornalley PJ, Bellavite P . Modification of the glyoxalase system during the functional activation of human neutrophils . Biochim. Biophys. Acta . 931 . 2 . 120–9 . 1987 . 3663711 . 10.1016/0167-4889(87)90198-4 .
• Valentine WN, Paglia DE, Neerhout RC, Konrad PN . Erythrocyte glyoxalase II deficiency with coincidental hereditary elliptocytosis . Blood . 36 . 6 . 797–808 . 1971 . 5485124 . 10.1182/blood.V36.6.797.797. free .
• Leoncini G . Platelet glyoxalases in thrombocytosis . Scandinavian Journal of Haematology . 33 . 1 . 91–4 . 1984 . 6463589 . 10.1111/j.1600-0609.1984.tb02216.x . vanc. Maresca M . Balestrero F . 3 . Armani . U. . Piana . A. .
• Board PG . Genetic polymorphism of human erythrocyte glyoxalase II . Am. J. Hum. Genet. . 32 . 5 . 690–4 . 1980 . 7424909 . 1686103 .
• Di Ilio C . Glyoxalase activities in tumor and non-tumor human urogenital tissues . Cancer Lett. . 96 . 2 . 189–93 . 1995 . 7585456 . 10.1016/0304-3835(95)03928-P . vanc. Angelucci S . Pennelli A . 3 . Zezza . Andrea . Tenaglia . Raffaele . Sacchetta . Paolo .
• Ridderström M . Molecular cloning, heterologous expression, and characterization of human glyoxalase II . J. Biol. Chem. . 271 . 1 . 319–23 . 1996 . 8550579 . 10.1074/jbc.271.1.319 . vanc. Saccucci F . Hellman U . 3 . Bergman . T . Principato . G . Mannervik . B . free .
• Cameron AD, Ridderström M, Olin B, Mannervik B . Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue . Structure . 7 . 9 . 1067–78 . 1999 . 10508780 . 10.1016/S0969-2126(99)80174-9 . free .
• Daniels RJ . Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 . Hum. Mol. Genet. . 10 . 4 . 339–52 . 2001 . 11157797 . 10.1093/hmg/10.4.339 . vanc. Peden JF . Lloyd C . 3 . Horsley . SW . Clark . K . Tufarelli . C . Kearney . L . Buckle . VJ . Doggett . NA . free .
• Rulli A . Expression of glyoxalase I and II in normal and breast cancer tissues . Breast Cancer Res. Treat. . 66 . 1 . 67–72 . 2001 . 11368412 . 10.1023/A:1010632919129 . vanc. Carli L . Romani R . 3 . Baroni . Tiziano . Giovannini . Elvio . Rosi . Gabriella . Talesa . Vincenzo . 10225506 .
• Scirè A . Effect of acidic phospholipids on the structural properties of recombinant cytosolic human glyoxalase II . Proteins . 48 . 1 . 126–33 . 2002 . 12012344 . 10.1002/prot.10149 . vanc. Saccucci F . Bertoli E . 3 . Cambria . Maria Teresa . Principato . Giovanni . d'Auria . Sabato . Tanfani . Fabio . 25251778 .
• Mearini E . Differing expression of enzymes of the glyoxalase system in superficial and invasive bladder carcinomas . Eur. J. Cancer . 38 . 14 . 1946–50 . 2002 . 12204678 . 10.1016/S0959-8049(02)00236-8 . vanc. Romani R . Mearini L . 3 . Antognelli . C . Zucchi . A . Baroni . T . Porena . M . Talesa . VN .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Cordell PA, Futers TS, Grant PJ, Pease RJ . The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II . J. Biol. Chem. . 279 . 27 . 28653–61 . 2004 . 15117945 . 10.1074/jbc.M403470200 . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .

Notes and References

1. Mulley JC, Callen DF . New regional localisations for HAGH and PGP on human chromosome 16 . Hum Genet . 74 . 4 . 423–4 . Feb 1987 . 3025077 . 10.1007/BF00280498 . 19620852 .
2. Honey NK, Shows TB . Assignment of the glyoxalase II gene (HAGH) to human chromosome 16 . Hum Genet . 58 . 4 . 358–61 . Apr 1982 . 7327557 . 10.1007/bf00282815. 10452468 .
3. Web site: Entrez Gene: HAGH hydroxyacylglutathione hydrolase.