HABP2 explained

Hyaluronan-binding protein 2 also known as factor VII activating protease (FSAP) is a protein that in humans is encoded by the HABP2 gene.^{[1] [2] [3]}

The protein encoded by this gene is an extracellular serine protease which binds hyaluronic acid. It is involved in cell adhesion. The protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. Two transcript variants utilizing alternative polyA sites exist for this gene.

Further reading

• Gupta S, Batchu RB, Datta K . Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface . Eur. J. Cell Biol. . 56 . 1 . 58–67 . 1992 . 1724753 .
• Sumiya J . Isolation and characterization of the plasma hyaluronan-binding protein (PHBP) gene (HABP2) . J. Biochem. . 122 . 5 . 983–90 . 1998 . 9443814 . 10.1093/oxfordjournals.jbchem.a021861. vanc. Asakawa S . Tobe T . 3 . Hashimoto . K . Saguchi . K . Choi-Miura . NH . Shimizu . Y . Minoshima . S . Shimizu . N .
• Choi-Miura NH . Identification of the substrates for plasma hyaluronan binding protein . Biol. Pharm. Bull. . 24 . 2 . 140–3 . 2001 . 11217080 . 10.1248/bpb.24.140 . vanc. Yoda M . Saito K . 3 . Takahashi . Katsuhiko . Tomita . Motowo . free.
• Choi-Miura NH . Proteolytic activation and inactivation of the serine protease activity of plasma hyaluronan binding protein . Biol. Pharm. Bull. . 24 . 5 . 448–52 . 2001 . 11379758 . 10.1248/bpb.24.448 . vanc. Takahashi K . Yoda M . 3 . Saito . Kiyomi . Mazda . Toshio . Tomita . Motowo . free .
• Roemisch J . The frequent Marburg I polymorphism impairs the pro-urokinase activating potency of the factor VII activating protease (FSAP) . Blood Coagul. Fibrinolysis . 13 . 5 . 433–41 . 2003 . 12138371 . 10.1097/00001721-200207000-00008 . vanc. Feussner A . Nerlich C . 3 . Stoehr . H.-A. . Weimer . T. . 39490260 .
• Wang KK . Novel candidate tumor marker genes for lung adenocarcinoma . Oncogene . 21 . 49 . 7598–604 . 2002 . 12386823 . 10.1038/sj.onc.1205953 . vanc. Liu N . Radulovich N . 3 . Wigle . Dennis A . Johnston . Michael R . Shepherd . Frances A . Minden . Mark D . Tsao . Ming-Sound . free .
• Etscheid M . The hyaluronan-binding serine protease from human plasma cleaves HMW and LMW kininogen and releases bradykinin . Biol. Chem. . 383 . 10 . 1633–43 . 2003 . 12452440 . 10.1515/BC.2002.184 . vanc. Beer N . Fink E . 3 . Seitz . R. . Dodt . J. . 18939354 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Willeit J . Marburg I polymorphism of factor VII--activating protease: a prominent risk predictor of carotid stenosis . Circulation . 107 . 5 . 667–70 . 2003 . 12578864 . 10.1161/01.CIR.0000055189.18831.B1 . vanc. Kiechl S . Weimer T . 3 . Mair . A . Santer . P . Wiedermann . CJ . Roemisch . J . free .
• Anderson NL . The human plasma proteome: a nonredundant list developed by combination of four separate sources . Mol. Cell. Proteomics . 3 . 4 . 311–26 . 2004 . 14718574 . 10.1074/mcp.M300127-MCP200 . vanc. Polanski M . Pieper R . 3 . Gatlin . T . Tirumalai . RS . Conrads . TP . Veenstra . TD . Adkins . JN . Pounds . JG . free .
• Deloukas P . The DNA sequence and comparative analysis of human chromosome 10 . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . vanc. Earthrowl ME . Grafham DV . 3 . Rubenfield . M. . French . L. . Steward . C. A. . Sims . S. K. . Jones . M. C. . Searle . S. . 2004Natur.429..375D . free .
• Hoppe B . Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism . Blood . 105 . 4 . 1549–51 . 2005 . 15486068 . 10.1182/blood-2004-08-3328 . vanc. Tolou F . Radtke H . 3 . Kiesewetter . H . Dörner . T . Salama . A . free.
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Ireland H . The factor VII activating protease G511E (Marburg) variant and cardiovascular risk . Thromb. Haemost. . 92 . 5 . 986–92 . 2005 . 15543324 . 10.1160/TH04-05-0275 . vanc. Miller GJ . Webb KE . 3 . Cooper . JA . Humphries . SE .
• Nakazawa F . Extracellular RNA is a natural cofactor for the (auto-)activation of Factor VII-activating protease (FSAP) . Biochem. J. . 385 . Pt 3 . 831–8 . 2005 . 15654766 . 10.1042/BJ20041021 . 1134760 . vanc. Kannemeier C . Shibamiya A . 3 . Song . Yutong . Tzima . Eleni . Schubert . Uwe . Koyama . Takatoshi . Niepmann . Michael . Trusheim . Heidi .
• van Minkelen R . The Marburg I polymorphism of factor VII-activating protease is not associated with venous thrombosis . Blood . 105 . 12 . 4898; author reply 4899 . 2005 . 15933067 . 10.1182/blood-2005-02-0576 . vanc. de Visser MC . Vos HL . 3 . Bertina . RM . Rosendaal . FR . free . 1887/5046 . free .
• Etscheid M, Beer N, Dodt J . The hyaluronan-binding protease upregulates ERK1/2 and PI3K/Akt signalling pathways in fibroblasts and stimulates cell proliferation and migration . Cell. Signal. . 17 . 12 . 1486–94 . 2006 . 16153533 . 10.1016/j.cellsig.2005.03.007 .

Notes and References

1. Choi-Miura NH, Tobe T, Sumiya J, Nakano Y, Sano Y, Mazda T, Tomita M . Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator . J Biochem . 119 . 6 . 1157–65 . Dec 1996 . 8827452 . 10.1093/oxfordjournals.jbchem.a021362.
2. Romisch J . Factor VII activating protease (FSAP): a novel protease in hemostasis . Biol Chem . 383 . 7–8 . 1119–24 . Nov 2002 . 12437095 . 10.1515/BC.2002.121 . 37767393 .
3. Web site: Entrez Gene: HABP2 hyaluronan binding protein 2.