H60 family explained

The histocompatibility 60 (H60) was originally identified as a transplant rejection antigen[1] and it is a family of murine cell surface glycoproteins contains three members: H60a, H60b, H60c. The genes encoding these proteins are located on murine chromosome 10.[2] H60 family members are related to MHC class I.[3] H60a and H60b consist of external α1α2 domain, a transmembrane segment, and a cytoplasmic domain. H60c is made up of α1α2 domain which is linked to the cell membrane by GPI anchor. All these proteins function as stress-induced ligands for NKG2D receptor.

Notes and References

  1. The molecular and functional characterization of a dominant minor H antigen, H60. Malarkannan. Subramaniam. 1998. J. Immunol. . 161 . 7 . 3501–9 . 10.4049/jimmunol.161.7.3501 . 9759870. 2202196 . free .
  2. Two Novel NKG2D Ligands of the Mouse H60 Family with Differential Expression Patterns and Binding Affinities to NKG2D. The Journal of Immunology. 2008-02-01. 0022-1767. 18209064. 1678–1685. 180. 3. 10.4049/jimmunol.180.3.1678. Akio. Takada. Shigeru. Yoshida. Mizuho. Kajikawa. Yukiko. Miyatake. Utano. Tomaru. Masaharu. Sakai. Hitoshi. Chiba. Katsumi. Maenaka. Daisuke. Kohda. free.
  3. Retinoic Acid Early Inducible Genes Define a Ligand Family for the Activating NKG2D Receptor in Mice. Immunity. 2000-01-06. 1074-7613. 10894171. 721–727. 12. 6. 10.1016/S1074-7613(00)80222-8. Adelheid. Cerwenka. Alexander B. H.. Bakker. Terri. McClanahan. Janet. Wagner. Jun. Wu. Joseph H.. Phillips. Lewis L.. Lanier. free.

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