HIST1H4F explained

Histone H4 is a protein that in humans is encoded by the HIST1H4F gene.^{[1] [2] [3] [4]}

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.^[5]

Further reading

• Pauli U, Chrysogelos S, Stein G, etal . Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. . Science . 236 . 4806 . 1308–11 . 1987 . 3035717 . 10.1126/science.3035717 . 1987Sci...236.1308P .
• Albig W, Doenecke D . The human histone gene cluster at the D6S105 locus. . Hum. Genet. . 101 . 3 . 284–94 . 1998 . 9439656 . 10.1007/s004390050630 . 38539096 .
• El Kharroubi A, Piras G, Zensen R, Martin MA . Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. . Mol. Cell. Biol. . 18 . 5 . 2535–44 . 1998 . 9566873 . 10.1128/mcb.18.5.2535. 110633 .
• Munakata T, Adachi N, Yokoyama N, etal . A human homologue of yeast anti-silencing factor has histone chaperone activity. . Genes Cells . 5 . 3 . 221–33 . 2000 . 10759893 . 10.1046/j.1365-2443.2000.00319.x . 20198031 . free .
• Deng L, de la Fuente C, Fu P, etal . Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. . Virology . 277 . 2 . 278–95 . 2001 . 11080476 . 10.1006/viro.2000.0593 . free .
• Deng L, Wang D, de la Fuente C, etal . Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. . Virology . 289 . 2 . 312–26 . 2001 . 11689053 . 10.1006/viro.2001.1129 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Yoon HG, Chan DW, Huang ZQ, etal . Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. . EMBO J. . 22 . 6 . 1336–46 . 2003 . 12628926 . 10.1093/emboj/cdg120 . 151047 .
• Umehara T, Horikoshi M . Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis. . J. Biol. Chem. . 278 . 37 . 35660–7 . 2003 . 12842904 . 10.1074/jbc.M303549200 . free .
• Lusic M, Marcello A, Cereseto A, Giacca M . Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. . EMBO J. . 22 . 24 . 6550–61 . 2004 . 14657027 . 10.1093/emboj/cdg631 . 291826 .
• Black BE, Foltz DR, Chakravarthy S, etal . Structural determinants for generating centromeric chromatin. . Nature . 430 . 6999 . 578–82 . 2004 . 15282608 . 10.1038/nature02766 . 2004Natur.430..578B . 4392941 .
• Le XF, Lammayot A, Gold D, etal . Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. . J. Biol. Chem. . 280 . 3 . 2092–104 . 2005 . 15504738 . 10.1074/jbc.M403080200 . free .
• Yoon HG, Choi Y, Cole PA, Wong J . Reading and function of a histone code involved in targeting corepressor complexes for repression. . Mol. Cell. Biol. . 25 . 1 . 324–35 . 2005 . 15601853 . 10.1128/MCB.25.1.324-335.2005 . 538779 .

Notes and References

1. Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D . Isolation and characterization of two human H1 histone genes within clusters of core histone genes . Genomics . 10 . 4 . 940–8 . Nov 1991 . 1916825 . 10.1016/0888-7543(91)90183-F .
2. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D . Human histone gene organization: nonregular arrangement within a large cluster . Genomics . 40 . 2 . 314–22 . Apr 1997 . 9119399 . 10.1006/geno.1996.4592 .
3. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ . The human and mouse replication-dependent histone genes . Genomics . 80 . 5 . 487–98 . Oct 2002 . 12408966 . 10.1016/S0888-7543(02)96850-3 .
4. Web site: Entrez Gene: HIST1H4F histone cluster 1, H4f.
5. Web site: Entrez Gene: HIST1H4F histone cluster 1, H4f.