HIST1H3I explained

Histone H3.1 is a protein that in humans is encoded by the HIST1H3I gene.^{[1] [2] [3] [4]}

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.

Further reading

• Lusic M, Marcello A, Cereseto A, Giacca M . Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter . The EMBO Journal . 22 . 24 . 6550–61 . December 2003 . 14657027 . 291826 . 10.1093/emboj/cdg631 .
• Deng L, Wang D, de la Fuente C, Wang L, Li H, Lee CG, Donnelly R, Wade JD, Lambert P, Kashanchi F . Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA . Virology . 289 . 2 . 312–26 . October 2001 . 11689053 . 10.1006/viro.2001.1129 . free .
• Deng L, de la Fuente C, Fu P, Wang L, Donnelly R, Wade JD, Lambert P, Li H, Lee CG, Kashanchi F . Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones . Virology . 277 . 2 . 278–95 . November 2000 . 11080476 . 10.1006/viro.2000.0593 . free .
• El Kharroubi A, Piras G, Zensen R, Martin MA . Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter . Molecular and Cellular Biology . 18 . 5 . 2535–44 . May 1998 . 9566873 . 110633 . 10.1128/mcb.18.5.2535 .

Notes and References

1. Albig W, Meergans T, Doenecke D . Characterization of the H1.5 gene completes the set of human H1 subtype genes . Gene . 184 . 2 . 141–8 . January 1997 . 9031620 . 10.1016/S0378-1119(96)00582-3 .
2. Albig W, Doenecke D . The human histone gene cluster at the D6S105 locus . Human Genetics . 101 . 3 . 284–94 . December 1997 . 9439656 . 10.1007/s004390050630 . 38539096 .
3. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ . The human and mouse replication-dependent histone genes . Genomics . 80 . 5 . 487–98 . November 2002 . 12408966 . 10.1016/S0888-7543(02)96850-3 .
4. Web site: Entrez Gene: HIST1H3I histone cluster 1, H3i.