HIST1H2BD explained

Histone H2B type 1-D is a protein that in humans is encoded by the HIST1H2BD gene.^{[1] [2] [3]}

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryote. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3.

Further reading

• Albig W . Human histone gene organization: nonregular arrangement within a large cluster . Genomics . 40 . 2 . 314–22 . 1997 . 9119399 . 10.1006/geno.1996.4592 . vanc. Kioschis P . Poustka A . 3 . Meergans . Konstanze . Doenecke . Detlef .
• Albig W, Doenecke D . The human histone gene cluster at the D6S105 locus . Hum. Genet. . 101 . 3 . 284–94 . 1998 . 9439656 . 10.1007/s004390050630 . 38539096 .
• El Kharroubi A, Piras G, Zensen R, Martin MA . Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter . Mol. Cell. Biol. . 18 . 5 . 2535–44 . 1998 . 9566873 . 10.1128/mcb.18.5.2535. 110633 .
• Lorain S . Core Histones and HIRIP3, a Novel Histone-Binding Protein, Directly Interact with WD Repeat Protein HIRA . Mol. Cell. Biol. . 18 . 9 . 5546–56 . 1998 . 9710638 . 10.1128/MCB.18.9.5546. 109139 . vanc. Quivy JP . Monier-Gavelle F . 3 . Scamps . C . Lécluse . Y . Almouzni . G . Lipinski . M .
• Deng L . Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones . Virology . 277 . 2 . 278–95 . 2001 . 11080476 . 10.1006/viro.2000.0593 . vanc. de la Fuente C . Fu P . 3 . Wang . L . Donnelly . R . Wade . JD . Lambert . P . Li . H . Lee . CG . free .
• Deng L . Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA . Virology . 289 . 2 . 312–26 . 2001 . 11689053 . 10.1006/viro.2001.1129 . vanc. Wang D . de la Fuente C . 3 . Wang . L . Li . H . Lee . CG . Donnelly . R . Wade . JD . Lambert . P . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Cheung WL . Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase . Cell . 113 . 4 . 507–17 . 2003 . 12757711 . 10.1016/S0092-8674(03)00355-6 . vanc. Ajiro K . Samejima K . 3 . Kloc . Malgorzata . Cheung . Peter . Mizzen . Craig A. . Beeser . Alexander . Etkin . Laurence D. . Chernoff . Jonathan . 21854 . free .
• Mungall AJ . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . vanc. Palmer SA . Sims SK . 3 . Edwards . C. A. . Ashurst . J. L. . Wilming . L. . Jones . M. C. . Horton . R. . Hunt . S. E. . 2003Natur.425..805M . free .
• Lusic M, Marcello A, Cereseto A, Giacca M . Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter . EMBO J. . 22 . 24 . 6550–61 . 2004 . 14657027 . 10.1093/emboj/cdg631 . 291826 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Andersen JS . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . vanc. Lam YW . Leung AK . 3 . Ong . Shao-En . Lyon . Carol E. . Lamond . Angus I. . Mann . Matthias . 2005Natur.433...77A . 4344740 .
• Golebiowski F, Kasprzak KS . Inhibition of core histones acetylation by carcinogenic nickel(II) . Mol. Cell. Biochem. . 279 . 1–2 . 133–9 . 2007 . 16283522 . 10.1007/s11010-005-8285-1 . 25071586 .
• Zhu B . Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation . Mol. Cell . 20 . 4 . 601–11 . 2006 . 16307923 . 10.1016/j.molcel.2005.09.025 . vanc. Zheng Y . Pham AD . 3 . Mandal . Subhrangsu S. . Erdjument-Bromage . Hediye . Tempst . Paul . Reinberg . Danny . free .
• Bonenfant D . Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry . Mol. Cell. Proteomics . 5 . 3 . 541–52 . 2006 . 16319397 . 10.1074/mcp.M500288-MCP200 . vanc. Coulot M . Towbin H . 3 . Schindler . P . Van Oostrum . J . free .
• Siuti N . Gene-specific characterization of human histone H2B by electron capture dissociation . J. Proteome Res. . 5 . 2 . 233–9 . 2006 . 16457587 . 10.1021/pr050268v . vanc. Roth MJ . Mizzen CA . 3 . Kelleher . Neil L. . Pesavento . James J. .
• Beck HC . Quantitative proteomic analysis of post-translational modifications of human histones . Mol. Cell. Proteomics . 5 . 7 . 1314–25 . 2006 . 16627869 . 10.1074/mcp.M600007-MCP200 . vanc. Nielsen EC . Matthiesen R . 3 . Jensen . LH . Sehested . M . Finn . P . Grauslund . M . Hansen . AM . Jensen . ON . free .
• Pavri R . Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II . Cell . 125 . 4 . 703–17 . 2006 . 16713563 . 10.1016/j.cell.2006.04.029 . vanc. Zhu B . Li G . 3 . Trojer . Patrick . Mandal . Subhrangsu . Shilatifard . Ali . Reinberg . Danny . 2614680 . free.

Notes and References

1. Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D . Isolation and characterization of two human H1 histone genes within clusters of core histone genes . Genomics . 10 . 4 . 940–8 . Nov 1991 . 1916825 . 10.1016/0888-7543(91)90183-F .
2. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ . The human and mouse replication-dependent histone genes . Genomics . 80 . 5 . 487–98 . Oct 2002 . 12408966 . 10.1016/S0888-7543(02)96850-3 .
3. Web site: Entrez Gene: HIST1H2BD histone cluster 1, H2bd.