Histone H2B type 1-C explained

Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BC gene.^{[1] [2] [3]}

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.^[3]

Further reading

• Ohe Y, Hayashi H, Iwai K . Human spleen histone H2B. Isolation and amino acid sequence . J. Biochem. . 85 . 2 . 615–24 . 1979 . 422550 . 10.1093/oxfordjournals.jbchem.a132371.
• Albig W, Doenecke D . The human histone gene cluster at the D6S105 locus . Hum. Genet. . 101 . 3 . 284–94 . 1998 . 9439656 . 10.1007/s004390050630 . 38539096 .
• El Kharroubi A, Piras G, Zensen R, Martin MA . Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter . Mol. Cell. Biol. . 18 . 5 . 2535–44 . 1998 . 9566873 . 10.1128/mcb.18.5.2535. 110633 .
• Deng L . Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones . Virology . 277 . 2 . 278–95 . 2001 . 11080476 . 10.1006/viro.2000.0593 . vanc. de la Fuente C . Fu P . 3 . Wang . L . Donnelly . R . Wade . JD . Lambert . P . Li . H . Lee . CG . free .
• Deng L . Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA . Virology . 289 . 2 . 312–26 . 2001 . 11689053 . 10.1006/viro.2001.1129 . vanc. Wang D . de la Fuente C . 3 . Wang . L . Li . H . Lee . CG . Donnelly . R . Wade . JD . Lambert . P . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Lusic M, Marcello A, Cereseto A, Giacca M . Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter . EMBO J. . 22 . 24 . 6550–61 . 2004 . 14657027 . 10.1093/emboj/cdg631 . 291826 .
• Ewing RM . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . vanc. Chu P . Elisma F . 3 . Li . Hongyan . Taylor . Paul . Climie . Shane . McBroom-Cerajewski . Linda . Robinson . Mark D . O'Connor . Liam .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Histone H2B type 1-C

Notes and References

1. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D . Human histone gene organization: nonregular arrangement within a large cluster . Genomics . 40 . 2 . 314–22 . Apr 1997 . 9119399 . 10.1006/geno.1996.4592 .
2. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ . The human and mouse replication-dependent histone genes . Genomics . 80 . 5 . 487–98 . Oct 2002 . 12408966 . 10.1016/S0888-7543(02)96850-3 .
3. Web site: Entrez Gene: HIST1H2BC histone cluster 1, H2bc.