H2AFB3 explained

H2A histone family, member B3 is a protein that in humans is encoded by the H2AFB3 gene.^[1]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most telomeric copy. [provided by RefSeq, Jul 2008].^[2]

Further reading

• Deng L, de la Fuente C, Fu P, Wang L, Donnelly R, Wade JD, Lambert P, Li H, Lee CG, Kashanchi F . Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones . Virology . 277 . 2 . 278–95 . November 2000 . 11080476 . 10.1006/viro.2000.0593 . free .
• Chadwick BP, Willard HF . A novel chromatin protein, distantly related to histone H2A, is largely excluded from the inactive X chromosome . The Journal of Cell Biology . 152 . 2 . 375–84 . January 2001 . 11266453 . 2199617 . 10.1083/jcb.152.2.375 .
• Deng L, Wang D, de la Fuente C, Wang L, Li H, Lee CG, Donnelly R, Wade JD, Lambert P, Kashanchi F . Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA . Virology . 289 . 2 . 312–26 . October 2001 . 11689053 . 10.1006/viro.2001.1129 . free .
• Lusic M, Marcello A, Cereseto A, Giacca M . Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter . The EMBO Journal . 22 . 24 . 6550–61 . December 2003 . 14657027 . 291826 . 10.1093/emboj/cdg631 .
• Bao Y, Konesky K, Park YJ, Rosu S, Dyer PN, Rangasamy D, Tremethick DJ, Laybourn PJ, Luger K . Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA . The EMBO Journal . 23 . 16 . 3314–24 . August 2004 . 15257289 . 514500 . 10.1038/sj.emboj.7600316 .
• Okuwaki M, Kato K, Shimahara H, Tate S, Nagata K . Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I . Molecular and Cellular Biology . 25 . 23 . 10639–51 . December 2005 . 16287874 . 1291234 . 10.1128/MCB.25.23.10639-10651.2005 .
• Naylor JA, Buck D, Green P, Williamson H, Bentley D, Giannelli F . Investigation of the factor VIII intron 22 repeated region (int22h) and the associated inversion junctions . Human Molecular Genetics . 4 . 7 . 1217–24 . July 1995 . 8528212 . 10.1093/hmg/4.7.1217 .
• El Kharroubi A, Piras G, Zensen R, Martin MA . Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter . Molecular and Cellular Biology . 18 . 5 . 2535–44 . May 1998 . 9566873 . 110633 . 10.1128/mcb.18.5.2535 .

Notes and References

1. Web site: Entrez Gene: H2A histone family, member B3. 2012-03-12 .
2. Web site: Entrez Gene: H2A histone family, member B3. 2012-03-12 .