HIST1H2AB explained

Histone H2A type 1-B/E is a protein that in humans is encoded by the HIST1H2AB gene.^{[1] [2] [3] [4]}

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.

Further reading

• Zhong R, Roeder RG, Heintz N . The primary structure and expression of four cloned human histone genes. . Nucleic Acids Res. . 11 . 21 . 7409–25 . 1984 . 6647026 . 10.1093/nar/11.21.7409. 326492 .
• El Kharroubi A, Piras G, Zensen R, Martin MA . Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. . Mol. Cell. Biol. . 18 . 5 . 2535–44 . 1998 . 9566873 . 10.1128/mcb.18.5.2535. 110633 .
• Deng L, de la Fuente C, Fu P, etal . Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. . Virology . 277 . 2 . 278–95 . 2001 . 11080476 . 10.1006/viro.2000.0593 . free .
• Deng L, Wang D, de la Fuente C, etal . Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. . Virology . 289 . 2 . 312–26 . 2001 . 11689053 . 10.1006/viro.2001.1129 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Lusic M, Marcello A, Cereseto A, Giacca M . Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. . EMBO J. . 22 . 24 . 6550–61 . 2004 . 14657027 . 10.1093/emboj/cdg631 . 291826 .
• Citterio E, Papait R, Nicassio F, etal . Np95 is a histone-binding protein endowed with ubiquitin ligase activity. . Mol. Cell. Biol. . 24 . 6 . 2526–35 . 2004 . 14993289 . 10.1128/MCB.24.6.2526-2535.2004. 355858 .
• Zhang Y, Griffin K, Mondal N, Parvin JD . Phosphorylation of histone H2A inhibits transcription on chromatin templates. . J. Biol. Chem. . 279 . 21 . 21866–72 . 2004 . 15010469 . 10.1074/jbc.M400099200 . free .
• Aihara H, Nakagawa T, Yasui K, etal . Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. . Genes Dev. . 18 . 8 . 877–88 . 2004 . 15078818 . 10.1101/gad.1184604 . 395847 .
• Wang H, Wang L, Erdjument-Bromage H, etal . Role of histone H2A ubiquitination in Polycomb silencing. . Nature . 431 . 7010 . 873–8 . 2004 . 15386022 . 10.1038/nature02985 . 2004Natur.431..873W . 4344378 .
• Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics. . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Hagiwara T, Hidaka Y, Yamada M . Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. . Biochemistry . 44 . 15 . 5827–34 . 2005 . 15823041 . 10.1021/bi047505c .
• Cao R, Tsukada Y, Zhang Y . Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. . Mol. Cell . 20 . 6 . 845–54 . 2006 . 16359901 . 10.1016/j.molcel.2005.12.002 . free .
• Bergink S, Salomons FA, Hoogstraten D, etal . DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. . Genes Dev. . 20 . 10 . 1343–52 . 2006 . 16702407 . 10.1101/gad.373706 . 1472908 .

Notes and References

1. Albig W, Doenecke D . The human histone gene cluster at the D6S105 locus . Hum Genet . 101 . 3 . 284–94 . Feb 1998 . 9439656 . 10.1007/s004390050630 . 38539096 .
2. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D . Human histone gene organization: nonregular arrangement within a large cluster . Genomics . 40 . 2 . 314–22 . Apr 1997 . 9119399 . 10.1006/geno.1996.4592 .
3. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ . The human and mouse replication-dependent histone genes . Genomics . 80 . 5 . 487–98 . Oct 2002 . 12408966 . 10.1016/S0888-7543(02)96850-3 .
4. Web site: Entrez Gene: HIST1H2AB histone cluster 1, H2ab.