HIST2H2AB explained

Histone H2A type 2-B is a protein that in humans is encoded by the HIST2H2AB gene.^{[1] [2]}

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element.

Further reading

• El Kharroubi A, Piras G, Zensen R, Martin MA . Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter . Mol. Cell. Biol. . 18 . 5 . 2535–44 . 1998 . 9566873 . 10.1128/mcb.18.5.2535. 110633 .
• Deng L . Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones . Virology . 277 . 2 . 278–95 . 2001 . 11080476 . 10.1006/viro.2000.0593 . vanc. de la Fuente C . Fu P . 3 . Wang . L . Donnelly . R . Wade . JD . Lambert . P . Li . H . Lee . CG . free .
• Deng L . Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA . Virology . 289 . 2 . 312–26 . 2001 . 11689053 . 10.1006/viro.2001.1129 . vanc. Wang D . de la Fuente C . 3 . Wang . L . Li . H . Lee . CG . Donnelly . R . Wade . JD . Lambert . P . free .
• Chen A . Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase . J. Biol. Chem. . 277 . 24 . 22085–92 . 2002 . 11927591 . 10.1074/jbc.M201252200 . vanc. Kleiman FE . Manley JL . 3 . Ouchi . T . Pan . ZQ . free .
• Lusic M, Marcello A, Cereseto A, Giacca M . Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter . EMBO J. . 22 . 24 . 6550–61 . 2004 . 14657027 . 10.1093/emboj/cdg631 . 291826 .
• Zhang Y, Griffin K, Mondal N, Parvin JD . Phosphorylation of histone H2A inhibits transcription on chromatin templates . J. Biol. Chem. . 279 . 21 . 21866–72 . 2004 . 15010469 . 10.1074/jbc.M400099200 . free .
• Aihara H . Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo . Genes Dev. . 18 . 8 . 877–88 . 2004 . 15078818 . 10.1101/gad.1184604 . 395847 . vanc. Nakagawa T . Yasui K . 3 . Ohta . T . Hirose . S . Dhomae . N . Takio . K . Kaneko . M . Takeshima . Y .
• Wang H . Role of histone H2A ubiquitination in Polycomb silencing . Nature . 431 . 7010 . 873–8 . 2004 . 15386022 . 10.1038/nature02985 . vanc. Wang L . Erdjument-Bromage H . 3 . Vidal . Miguel . Tempst . Paul . Jones . Richard S. . Zhang . Yi . 2004Natur.431..873W . 4344378 .
• Hagiwara T, Hidaka Y, Yamada M . Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes . Biochemistry . 44 . 15 . 5827–34 . 2005 . 15823041 . 10.1021/bi047505c .
• Cao R, Tsukada Y, Zhang Y . Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing . Mol. Cell . 20 . 6 . 845–54 . 2006 . 16359901 . 10.1016/j.molcel.2005.12.002 . free .
• Bergink S . DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A . Genes Dev. . 20 . 10 . 1343–52 . 2006 . 16702407 . 10.1101/gad.373706 . 1472908 . vanc. Salomons FA . Hoogstraten D . 3 . Groothuis . TA . De Waard . H . Wu . J . Yuan . L . Citterio . E . Houtsmuller . AB .
• Gregory SG . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . vanc. Barlow KF . McLay KE . 3 . Kaul . R. . Swarbreck . D. . Dunham . A. . Scott . C. E. . Howe . K. L. . Woodfine . K. . 2006Natur.441..315G . free .

Notes and References

1. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ . The human and mouse replication-dependent histone genes . Genomics . 80 . 5 . 487–98 . Oct 2002 . 12408966 . 10.1016/S0888-7543(02)96850-3 .
2. Web site: Entrez Gene: HIST2H2AB histone cluster 2, H2ab.