H1299 Explained

H1299, also known as NCI-H1299^{[1] [2]} or CRL-5803,^[3] is a human non-small cell lung carcinoma cell line derived from the lymph node, which is widely used in research.^[4]

As with other immortalized cell lines, H1299 cells can divide indefinitely. These cells have a homozygous partial deletion of the TP53 gene and as a result, do not express the tumor suppressor p53 protein which in part accounts for their proliferative propensity.^[5] These cells have also been reported to secrete the peptide hormone neuromedin B (NMB), but not gastrin releasing peptide (GRP).^[4]

External links

• Cellosaurus entry for H1299

Notes and References

1. NCI-Navy Medical Oncology Branch cell line supplement . J. Cell. Biochem. Suppl. . 24 . 1–291 . 1996 . 8965489 .
2. Web site: ATCC Advanced Catalog Search . 2009-01-07.
3. Web site: CRL-5803/NCI-H1299 cell line . LGC Promochem: Cell Biology Collection . . 2008-06-22.
4. Giaccone G, Battey J, Gazdar AF, Oie H, Draoui M, Moody TW . Neuromedin B is present in lung cancer cell lines . Cancer Res. . 52 . 9 Suppl . 2732s–2736s . May 1992 . 1563005 .
5. Lin DL, Chang C . p53 is a mediator for radiation-repressed human TR2 orphan receptor expression in MCF-7 cells, a new pathway from tumor suppressor to member of the steroid receptor superfamily . J. Biol. Chem. . 271 . 25 . 14649–52 . June 1996 . 8663350 . 10.1074/jbc.271.25.14649 . free .