H1FOO explained

Histone H1oo is a protein that in humans is encoded by the H1FOO gene.^{[1] [2]}

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes.^[2]

It incorporates into sperm chromatin after fertilisation.^[3]

Further reading

• Teranishi T, Tanaka M, Kimoto S, etal . Rapid replacement of somatic linker histones with the oocyte-specific linker histone H1foo in nuclear transfer. . Dev. Biol. . 266 . 1 . 76–86 . 2004 . 14729479 . 10.1016/j.ydbio.2003.10.004 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . free .
• Tanaka Y, Kato S, Tanaka M, etal . Structure and expression of the human oocyte-specific histone H1 gene elucidated by direct RT-nested PCR of a single oocyte . Biochem. Biophys. Res. Commun. . 304 . 2 . 351–7 . 2003 . 12711322 . 10.1016/S0006-291X(03)00610-7 .
• Tanaka M, Kihara M, Hennebold JD, etal . H1FOO is coupled to the initiation of oocytic growth . Biol. Reprod. . 72 . 1 . 135–42 . 2005 . 15371275 . 10.1095/biolreprod.104.032474 . free .
• Gao S, Chung YG, Parseghian MH, etal . Rapid H1 linker histone transitions following fertilization or somatic cell nuclear transfer: evidence for a uniform developmental program in mice . Dev. Biol. . 266 . 1 . 62–75 . 2004 . 14729478 . 10.1016/j.ydbio.2003.10.003 . free .

Notes and References

1. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ . The human and mouse replication-dependent histone genes . Genomics . 80 . 5 . 487–98 . November 2002 . 12408966 . 10.1016/S0888-7543(02)96850-3.
2. Web site: Entrez Gene: H1 histone family.
3. Mizusawa Y, Kuji N, Tanaka Y, etal . Expression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization . Fertil Steril . 93 . 4 . 1134–1141 . March 2010 . 19147139 . 10.1016/j.fertnstert.2008.11.028 . free .