Horton Corwin Hinshaw Explained

Horton Corwin Hinshaw Sr. (August 1, 1902, Iowa Falls, Iowa – December 28, 2000, San Rafael, California) was an American pulmonologist, known for the use of streptomycin as the first effective antibiotic for the treatment of tuberculosis (TB).[1] [2]

Biography

H. Corwin Hinshaw was born into a Quaker family[3] with roots in Quaker communities in North Carolina and Massachusetts. Some of his ancestors were among the first English colonists to settle on the eastern part of Long Island, near Horton's Point (where the Horton Point lighthouse is located).[1] As part of a mostly Quaker community,[3] he grew up on an apple farm[1] near Greenleaf, Idaho[3] and graduated from Greenleaf Friends Academy. In 1923 he graduated with a B.S. from the College of Idaho.[1] From 1923 to 1924 he studied at the University of Pittsburgh. At the University of California, Berkeley, he graduated in 1926 with an M.Sc.[3] and in 1927 with a Ph.D. in parasitology and was very briefly a faculty member as an instructor, before he went to Lebanon. There he taught at the American University of Beirut from 1927 to 1928 as an assistant professor[1] and from 1928 to 1932 as an associate professor of parasitology.[4] Upon returning to the United States he earned, within 2 years, an M.D. in 1933 from the medical school of the University of Pennsylvania.[1] In 1933 Hinshaw, as a specialist in lung diseases, joined the staff of the Mayo Clinic. There he worked with William Hugh Feldman on animal models of tuberculosis infection and was an associate professor of medicine until 1949.[5]

When streptomycin was isolated from Streptomyces griseus by Albert Schatz, Elizabeth Bugie, and Selman Waksman at Rutgers University,[6] Hinshaw and William Hugh Feldman, working together at the Mayo Clinic, requested a sample of streptomycin for testing in their guinea pig animal model of tuberculosis infection. After streptomycin proved effective for treating infected guinea pigs, Karl Hamilton Pfuetze, M.D. (1908–1990), superintendent and medical director at the Mineral Springs Sanatorium in Cannon Falls, Minnesota, contacted Dr. Hinshaw, in October 1945, concerning Pfuetze's tuberculosis patient Patricia "Patsy" Jane Thomas (1922–1966).

Patricia Thomas married Robert Ward Stockdale on October 8, 1947, in Mower County, Minnesota. The Stockdales had two daughters and a son.[7]

In 1949 Hinshaw moved with his family to Palo Alto, California and was affiliated with Stanford University School of Medicine as a clinical professor of medicine and head of the division of chest diseases from 1949 to 1959. In 1959 he moved to San Francisco and, at 450 Sutter Street, had an active internal medicine practice specializing in pulmonology in collaboration with his elder son, H. Corwin Hinshaw, Jr., M.D. Simultaneously, Dr. Hinshaw, Sr. was a clinical professor at the University of California, San Francisco,[1] until he retired as professor emeritus in 1979.[8]

He was the author or coauthor of more than 200 refereed articles. His textbook The Diseases of Chest (1st edition, 1956), coauthored with L. Henry Garland, was a pulmonary standard for many years.[1]

Hinshaw served as the president of the American Trudeau Society (rename in 1960 the American Thoracic Society during 1948 to 1949 and received the Society's Trudeau Medal in 1958. In 1980 he was elected to the American Lung Association's Hall of Fame. In 1947 he was nominated for a Nobel Prize by Melvin Starkey Henderson, Henry William Meyerding (1884–1969), and Robert Delevan Mussey (1916–2015).[9]

On August 6, 1924, in Pocatello, Hinshaw married Dorothy Kate Youmans (1902–1994). They had two sons and two daughters. Both sons became physicians. H. Corwin Hinshaw, Jr., M.D. (born 1927) shared his father's medical practice in San Francisco.[1] William Ezra Hinshaw, M.D. (1937–1982)[3] became an anesthesiologist. Barbara Hinshaw Baird (1931–1993) was a special-education resource specialist. Dorothy Hinshaw Patent (born 1940) is a zoologist and author of more than 100 nonfiction books for children.[8]

Selected publications

Articles

Books

References

  1. Auwaerter, Paul G.. 6736001. 2019. Horton Corwin Hinshaw, MD: 1902 – 2000. Transactions of the American Clinical and Climatological Association. 130. cvi.
  2. Murray, J. F.. John F. Murray. Schraufnagel, D. E.. Hopewell, P. C.. 2015. Treatment of tuberculosis. A historical perspective. Annals of the American Thoracic Society. 12. 12. 1749–1759. 10.1513/AnnalsATS.201509-632PS. 26653188. (See first 3 paragraphs of section Chemotherapy.)
  3. Web site: Horton Corwin Hinshaw. rawbw.com.
  4. Web site: Pathology and Laboratory Medicine at the American University of Beirut 1866–2015. Zaatari, Ghazi.
  5. News: H. Corwin Hinshaw, 98; Pioneered Treating TB With Streptomycin. Saxon, Wolfgang. The New York Times . January 15, 2001.
  6. Am J Respir Crit Care Med. 2004. 169. 11. 1181–1186. 15161611. 10.1164/rccm.200402-140OE. A century of tuberculosis. Murray, John F..
  7. Web site: Reflections on the past — first case with a new drug. September 2015. Discovery's Edge, Mayo Clinic's Research Magazine.
  8. News: Perlman, David. Obituary. Dr. H. Corwin Hinshaw. San Francisco Chronicle. January 11, 2001.
  9. Web site: H. Corwin Hinshaw. Nomination Archive, The Nobel Prize.
  10. Review of Diseases of the Chest by H. Corwin Hinshaw and L. Henry Garland. Western Journal of Medicine. August 1956. 85. 2. 144. 1531885.
  11. Zorab, P. A.. Review of Diseases of the Chest, 3rd edition, by H. Corwin Hinshaw. Proc. R. Soc. Med.. 63. May 1970. 544. 10.1177/003591577006300560. 200179737. free.

External links

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