| Guye | |
| Pushpin Map: | France#France Bourgogne-Franche-Comté |
| Source1 Location: | Sainte-Hélène |
| Source1 Coordinates: | 46.768°N 4.646°W |
| Mouth Location: | Grosne |
| Mouth Coordinates: | 46.5694°N 4.6614°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | France |
| Length: | 46.6km (29miles) |
| Basin Size: | 430km2 |
The Guye (in French pronounced as /ɡi/) is a 46.6km (29miles) long river in the Saône-et-Loire département, central eastern France. It flows primarily south, before turning east-northeast near Salornay-sur-Guye and flowing into the Grosne. It is a left tributary of the Grosne into which it flows between Malay and Savigny-sur-Grosne.
The following communes, ordered from source to mouth, lie along the Guye: