| Gustavo de Simone | |
| Fullname: | Gustavo Daniel de Simone Horn |
| Birth Date: | April 23, 1948 |
| Birth Place: | Montevideo, Uruguay |
| Position: | Defender |
| Years1: | 1969–1974 |
| Years2: | 1975 |
| Clubs2: | Chacarita Juniors |
| Caps2: | 24 |
| Goals2: | 0 |
| Nationalyears1: | 1973–1974 |
| Nationalteam1: | Uruguay |
| Nationalcaps1: | 8 |
| Nationalgoals1: | 0 |
| Manageryears1: | 1986 |
| Managerclubs1: | Herediano |
| Manageryears2: | 1987 |
| Managerclubs2: | Cartaginés |
| Manageryears3: | 1987–1989 |
| Managerclubs3: | Costa Rica |
| Manageryears4: | 1989–1990 |
| Managerclubs4: | Jerez Industrial |
| Manageryears5: | 1990 |
| Managerclubs5: | Huesca |
| Manageryears6: | 1991 |
| Managerclubs6: | Xerez |
| Manageryears7: | 1992 |
| Managerclubs7: | Panama |
| Manageryears8: | 1995–1996 |
| Managerclubs8: | Cúcuta |
| Manageryears9: | 2002–2003 |
| Managerclubs9: | Sagrada Familia |
| Manageryears10: | 2003 |
| Managerclubs10: | Luis Ángel Firpo |
| Manageryears11: | 2006–2007 |
| Managerclubs11: | Jalapa |
| Manageryears12: | 2008 |
| Managerclubs12: | Atlético Balboa |
| Manageryears13: | 2009–2010 |
| Managerclubs13: | Nejapa |
| Manageryears14: | 2015–2016 |
| Managerclubs14: | Municipal Grecia |
Gustavo Daniel de Simone Horn (born April 23, 1948) is a Uruguayan football coach and former national team player.
As a player, he had a short stint in Argentina with Chacarita Juniors where he played 24 league games.
Desimone represented his country in 3 FIFA World Cup qualification matches.