| Official Name: | Guisti جويستي |
| Settlement Type: | Village |
| Pushpin Map: | Djibouti |
| Pushpin Label Position: | bottom |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Djibouti |
| Subdivision Type: | Country |
| Subdivision Type1: | Region |
| Subdivision Name: | Djibouti |
| Subdivision Name1: | Ali Sabieh |
| Population As Of: | 2019 |
| Population Total: | 811 |
| Coordinates: | 11.0139°N 42.9597°W |
| Elevation M: | 448 |
Guisti (Arabic: جويستي) is a town located in southeastern of Ali Sabieh Region. It is situated about 32 kilometres (20 miles) Southeast of Ali Sabieh, near the borders with Somaliland and Ethiopia.
The town lies along on a river. Nearby towns and villages include Holhol (42 km), Assamo (18 km) and Ali Adde (17 km).
Guisti is in the Region of Ali Sabieh, its situated on a spur of a plateau, an upland characterized by one major wadi which run beside it. Guisti is near the borders of Somaliland to the east and Ethiopia to the south. Much of the landscape is rocky and arid, with desert vegetation and wildlife.
Guisti has a hot arid climate (Köppen: BWh) with hot and dry, prolonged summers and mild winters.
As of 2012, the population of Guisti has been estimated to be 500. The town inhabitants belong to various mainly Afro-Asiatic-speaking ethnic groups, with the Issa Somali predominant.