| Noc: | GBS |
| Nocname: | Comité Olímpico da Guiné-Bissau |
| Games: | Summer Olympics |
| Year: | 2000 |
| Location: | Sydney |
| Flagbearer: | Talata Embalo |
| Gold: | 0 |
| Silver: | 0 |
| Bronze: | 0 |
| Appearances: | auto |
| App Begin Year: | 1996 |
Guinea-Bissau competed at the 2000 Summer Olympics in Sydney, Australia.
See main article: Athletics at the 2000 Summer Olympics.
See main article: Wrestling at the 2000 Summer Olympics.