| Guillermo Padula | |
| Fullname: | Guillermo Padula Lenna |
| Birth Date: | 16 September 1997 |
| Birth Place: | Colonia del Sacramento, Uruguay |
| Height: | 1.81 m |
| Position: | Centre back |
| Currentclub: | La Luz |
| Clubnumber: | 3 |
| Youthclubs1: | Plaza Colonia |
| Years1: | 2014–2018 |
| Clubs1: | Plaza Colonia |
| Caps1: | 71 |
| Goals1: | 2 |
| Years2: | 2019 |
| Clubs2: | Mendrisio |
| Caps2: | 12 |
| Goals2: | 0 |
| Years3: | 2019–2020 |
| Clubs3: | Bellinzona |
| Caps3: | 7 |
| Goals3: | 0 |
| Years4: | 2020 |
| Clubs4: | Paradiso |
| Caps4: | 0 |
| Goals4: | 0 |
| Years5: | 2020–2022 |
| Clubs5: | Schaffhausen |
| Caps5: | 54 |
| Goals5: | 3 |
| Years6: | 2022–2023 |
| Clubs6: | Bellinzona |
| Caps6: | 17 |
| Goals6: | 1 |
| Years7: | 2023 |
| Clubs7: | → Schaffhausen (loan) |
| Caps7: | 12 |
| Goals7: | 1 |
| Years8: | 2023– |
| Clubs8: | La Luz |
| Caps8: | 1 |
| Goals8: | 1 |
| Nationalyears1: | 2015 |
| Nationalcaps1: | 1 |
| Nationalgoals1: | 0 |
| Nationalyears2: | 2016 |
| Nationalcaps2: | 3 |
| Nationalgoals2: | 0 |
| Pcupdate: | 3 September 2023 |
Guillermo Padula Lenna (born 16 September 1997) is a Uruguayan footballer who plays as a centre back for La Luz.
Padula started his career with Uruguayan second division side Plaza Colonia, helping them earn promotion and win the 2015–16 Uruguayan Primera División. On 5 April 2014, Padula made his league debut for Plaza Colonia during a 1-0 win over Rampla Juniors. On 27 September 2015, Padula scored his first goal for Plaza Colonia during a 1-1 draw with Juventud (Las Piedras). After that, he signed for FC Mendrisio in the Swiss fourth division.
In 2019, Padula signed for Swiss third division club Bellinzona.
Before the second half of 2019–20, he signed for FC Paradiso in the Swiss fourth division.
In 2020, he signed for Swiss second division team FCS.