| Guillermo Pérez de Arce | |
| Birth Date: | 1906 10, df=y |
| Birth Place: | Santiago, Chile |
| Death Place: | Santiago, Chile |
| Office1: | President of the Senate |
| Term Start1: | 8 April 1958 |
| Term End1: | 26 November 1958 |
| Predecessor1: | Fernando Alessandri Rodríguez |
| Successor1: | Hernán Videla Lira |
| Office2: | Member of the Senate of Chile |
| Constituency2: | 5th Provincial Agrupation |
| Term Start2: | 15 May 1953 |
| Term End2: | 15 May 1961 |
| Party: | Agrarian Labor Party Liberal Party |
| Occupation: | Politician |
| Spouse: | Virginia Letelier |
Guillermo Pérez de Arce Plummer (born 3 October 1906 – 10 June 1994) was a Chilean politician and entrepreneur who served as President of the Senate of Chile.