| Guillermo Méndez | |
| Fullname: | Guillermo Andrés Méndez Aguilera |
| Birth Date: | 26 August 1994 |
| Birth Place: | Paysandú, Uruguay |
| Position: | Attacking midfielder |
| Currentclub: | Unión Santa Fe |
| Clubnumber: | 25 |
| Youthclubs1: | Nacional |
| Years1: | 2012–2014 |
| Clubs1: | Standard Liège |
| Caps1: | 0 |
| Goals1: | 0 |
| Years2: | 2013 |
| Clubs2: | → Sint-Truiden (loan) |
| Caps2: | 19 |
| Goals2: | 3 |
| Years3: | 2014 |
| Clubs3: | → Alcorcón (loan) |
| Caps3: | 1 |
| Goals3: | 0 |
| Years4: | 2014–2017 |
| Years5: | 2017– |
| Clubs5: | Unión Santa Fe |
| Caps5: | 2 |
| Goals5: | 0 |
| Nationalyears1: | 2011 |
| Nationalcaps1: | 16 |
| Nationalgoals1: | 2 |
| Pcupdate: | 13:40, 14 May 2017 (UTC) |
Guillermo Andrés Méndez Aguilera (born 26 August 1994 in Paysandú, Uruguay) is a Uruguayan footballer who plays for Unión Santa Fe.