| Guillermo Hernández | |
| Fullname: | Guillermo Alejandro Hernández Sánchez |
| Birth Date: | 25 June 1942 |
| Birth Place: | Zacoalco de Torres, Jalisco, Mexico |
| Position: | Defender |
| Years1: | 1963–1967 |
| Years2: | 1967–1969 |
| Years3: | 1969–1974 |
| Clubs1: | Atlas |
| Clubs2: | Veracruz |
| Clubs3: | América |
| Nationalyears1: | 1966–1973 |
| Nationalteam1: | Mexico |
| Nationalcaps1: | 55 |
| Nationalgoals1: | 2 |
Guillermo Alejandro Hernández Sánchez (born June 25, 1942) is a Mexican former football defender, who played for the Mexico national team between 1966 and 1973, gaining 55 caps and scoring 2 goals. He was part of the Mexico squad for the 1966 and 1970 World Cups.