| Honorific-Prefix: | The Most Excellent |
| Guillermo Fernández Vara | |
| Office: | President of the Autonomous Government of Extremadura |
| Term Start: | 5 July 2015 |
| Term End: | 14 July 2023 |
| Predecessor: | José Antonio Monago |
| Successor: | María Guardiola |
| Monarch1: | Juan Carlos I |
| Term Start1: | 29 June 2007 |
| Term End1: | 7 July 2011 |
| Predecessor1: | Juan Carlos Rodríguez Ibarra |
| Successor1: | José Antonio Monago |
| Office2: | Secretary-General of the Socialist Workers' Party of Extremadura |
| Term Start2: | 19 July 2008 |
| Predecessor2: | Juan Carlos Rodríguez Ibarra |
| Office3: | Councillor of Health and Consumption of the Autonomous Government of Extremadura |
| Term Start3: | 21 July 1999 |
| Term End3: | 29 June 2007 |
| Predecessor3: | Office created |
| Successor3: | María Jesús Mejuto Carril |
| President3: | Juan Carlos Rodríguez Ibarra |
| Office4: | Councillor of Social Welfare of the Autonomous Government of Extremadura |
| Term Start4: | 12 January 1996 |
| Term End4: | 21 July 1999 |
| Predecessor4: | Maria Emilia Manzano Pereira |
| Successor4: | Ana Garrido Chamorro |
| President4: | Juan Carlos Rodríguez Ibarra |
| Office5: | Member of the Assembly of Extremadura |
| Term Start5: | 17 June 2003 |
| Constituency5: | Badajoz |
| Birth Date: | 6 October 1958 |
| Birth Place: | Olivenza, Extremadura, Spain |
| Nationality: | Spanish |
| Party: | PSOE |
| Alma Mater: | University of Córdoba |
| Office6: | Member of the Senate |
| Term Start6: | 20 July 2023 |
| Constituency6: | Assembly of Extremadura |
Guillermo Fernández Vara (born 6 October 1958) is a Spanish politician from the Spanish Socialist Workers' Party who was the President of the Autonomous Government of Extremadura between 2015 and 2023. He previously served as the President of Extremadura from 2007 to 2011.[1] Fernández had also previously served as Minister for Health (1995 to 1996) and Social Security (1996 to 1999) in Extremaduran autonomous governments.[2]
He studied medicine at the University of Córdoba.